Nagata Hydrocyanation

W. Nagata et al., Tetrahedron Letters 1962, 461.

Alkylaluminum-mediated 1,4-addition of hydrogen cyanide to α,β-unsaturated carbonyl compounds:



Early review: W. Nagata, M. Yoshioka, Org. React. 25, 255-476 (1977). Synthetic application: T. F. Gallagher, J. L. Adams, J. Org. Chem. 57, 3347 (1992). Cf. Michael Reaction.