Nef Synthesis

J. U. Nef, Ann. 308, 281 (1899).

Addition of sodium acetylides to aldehydes and ketones to yield acetylenic carbinols; occasionally and erroneously referred to as the Nef reaction, q.v.:



Farbenfabriken Bayer, DE 280226; DE 285770 (1913); J. H. Saunders, Org. Syn. 20, 40 (1940); A. W. Johnson, The Chemistry of the Acetylenic Compounds (London, 1946) p 11; C. D. Hurd, W. D. McPhee, J. Am. Chem. Soc. 69, 239 (1947); W. Oroschnik, A. O. Mebane, ibid. 71, 2062 (1949); R. A. Raphael, Acetylenic Compounds in Organic Synthesis (London, 1955) p 10. Cf. Arens-van Dorp Synthesis; Favorskii-Babayan Synthesis.