Negishi Cross Coupling

E. Negishi et al., J. Org. Chem. 42, 1821 (1977).

Formation of unsymmetric biaryls by cross coupling arylhalides with arylzinc reagents in presence of catalytic Ni or Pd:



Synthetic application: S. Superchi et al., Tetrahedron Letters 37, 6057 (1996); J. A. Miller, R. P. Farrell, ibid. 39, 6441 (1998). Extension to additional functional groups: E. Negishi, Acc. Chem. Res. 15, 340 (1982). Review: P. Knochel, R. D. Singer, Chem. Rev. 93, 2117-2188 (1993); idem et al., Ber. 130, 1021-1027 (1997).