Ritter Reaction

J. J. Ritter, P. P. Minieri, J. Am. Chem. Soc. 70, 4045 (1948); J. J. Ritter, J. Kalish, ibid. 4048.

Synthesis of amides from nitriles and alcohols or alkenes in strongly acidic media:



Reviews: L. I. Krimen, D. J. Cota, Org. React. 17, 213-325 (1969); R. C. Larock, W. W. Leong, Comp. Org. Syn. 4, 292-294 (1991); R. Bishop, ibid. 6, 261-300 (1991). Synthetic applications: S. Top, G. Jaouen, J. Org. Chem. 46, 78 (1981); D. M. Fink, R. C. Effland, Synth. Commun. 24, 2793 (1994); W. M. Samaniego et al., Tetrahedron Letters 35, 6967 (1994).