Skraup Reaction

Z. H. Skraup, Ber. 13, 2086 (1880).

Synthesis of quinolines from aromatic amines, glycerol, an oxidizing agent and sulfuric acid:



Early review: R. H. F. Manske, M. Kulka, Org. React. 7, 80-99 (1953). G. M. Badger et al., Aust. J. Chem. 16, 814, 828 (1963); M. Wahren, Tetrahedron 20, 2773 (1964); E. B. Mullock et al., J. Chem. Soc. C 1970, 829; N. P. Buu-Hoi et al., J. Chem. Soc. Perkin Trans. I 1972, 260, 263. Cf. Bischler-Napieralski Reaction.