Datasqueeze 2.2 is a graphical interface for analyzing data from 2D x-ray diffraction detectors (wire, image plate, CCD), running on Windows, Linux, and Macintosh OS X. The interface is simple and intuitive, and the program is easy to use even for those new to x-ray diffraction analysis. Datasqueeze is particularly useful for the analysis of powder diffraction data, diffuse scattering from polymers or liquid crystals, or small-angle scattering from colloids, polymers, gels, or solutions.