n-Propyl (CAS no.: ), which is also called as Benzene, propyl-, could be produced through the following synthesis routes.

In a dry 3-l. flask, fitted with a mercury-sealed stirrer, a 500-cc. dropping funnel, and a condenser provided at its upper end with a drying tube containing a mixture of calcium chloride and soda-lime, is placed 48.6 g. (2 atoms) of magnesium turnings. There are then added 200 cc. of dry ether, a small crystal of iodine, and about 25 cc. of a solution of 253 g. (230 cc., 2 moles) of freshly distilled benzyl chloride in 1 l. of dry ether. If the reaction does not start at once, the flask is partially immersed in a bath containing water heated to about 40°. As soon as the ether begins to boil, and reaction sets in, the bath is removed and stirring is commenced. The remainder of the benzyl chloride in ether can be added during the course of one-half hour if the reaction is regulated by cooling the greater part of the flask by immersion in ice water. The reaction will continue for about fifteen minutes after all the benzyl chloride has been added, and then the mixture is refluxed gently for about fifteen minutes.

To the stirred benzylmagnesium chloride is then added 616 g. (522 cc., 4 moles) of freshly distilled diethyl sulfate. The addition of diethyl sulfate is so regulated that gentle refluxing takes place throughout the reaction. Once reaction is started with a few cubic centimeters of diethyl sulfate, it is necessary to cool the reaction flask by ice water in order to complete addition within about one hour. When all the ester has been added, stirring is continued with gentle boiling for fifteen minutes.

The cooled mixture is next poured, with stirring, upon a mixture of 1 kg. of crushed ice, 1 l. of water, and 200 cc. of concentrated hydrochloric acid. After stirring a few minutes to dissolve the sludge, the major part of the water layer is siphoned off and the ethereal solution is separated. The water layer is washed once with about 50 cc. of ether, and this washing is added to the ethereal solution of n-propylbenzene. The ether is removed by distillation from a water or steam bath through a fractionating column. The residue is poured into 1 l. of 10 per cent sodium hydroxide solution in about 50 per cent alcohol, and this mixture is refluxed for one hour. After the n-propylbenzene is thrown out by the addition of a large volume of water, the hydrocarbon is separated, combined with an ether extract of the aqueous layer, dried by standing over 10–15 g. of solid potassium hydroxide, and fractionally distilled through an efficient column. The yield of n-propylbenzene, distilling at 155–160°, is 165–180 g. (70–75 per cent of the theoretical amount).