- Production Method of Salmeterol
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(CAS NO.: ), with other name of , 4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-, (+-)-, could be produced through many synthetic methods.
Following is one of the synthesis routes:
(I) could react with 1,6-di in the presence of NaH in THF to produce the ether derivative (III), which is then condensed with 5-(2-amino-1-hydroxyethyl)-2-hydroxybenzyl alcohol (IV) by means of KI and triethylamine in hot DMF.
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