aceponate (CAS NO.: ), with its systematic name of 11beta,17,21-Trihydroxy pregn-4-ene-3,20-dione 21-acetate 17-propionate, could be produced through many synthetic methods.

Following is one of the synthesis routes: 
Hydrocortisone (I) reacts with ethyl orthopropionate (EOP) / p-toluenesulfonic acid (p-TsOH) in DMF to produce the orthoester (II), which is cleaved by treating with a trisodium citrate (TSC) - HCl buffer to hydrocortisone 17-propionate (III). Subsequent acetylation by acetic anhydride/1,4-diazabicyclo[2.2.2]octane (DABCO) in DMF yields hydrocortisone 17-propionate 21-acetate.