- Production Method of Benzoylacetanilide
-
Benzoyl (CAS NO.: ), which is also known as Acetanilide, α-benzoyl-, could be produced through the following synthetic routes.
A mixture of 105.7 g. (0.55 mole) of and 46.6 g. (0.5 mole) of aniline is placed in the dropping funnel D (Fig.4) at the top of the continuous reactor after the column has been heated to 135° (transformer set at 80 volts). The reactants are then admitted to the column during about 15 minutes (this corresponds to a rate of amide formation of 396–400 g. per hour). Alcohol distils noticeably from the column during the addition and collects in flask G. At the completion of the reaction, 100 ml. of xylene is passed through the hot column to rinse out the residual amide. An additional 200 ml. of xylene is added to the receiver C, and solution is effected by warming. After the solution has been cooled enough to induce crystallization, 100 ml. of petroleum ether (b.p. 35–60°) is added with manual stirring. The mixture is chilled to 15°, then the crystalline product is separated by suction filtration and washed 300–400 ml. of petroleum ether. The yield is 99–100 g. (83–84%), m.p. 106–106.5°. The melting point of this product is not altered by recrystallization from benzene.
Prev:No record
Next:No record - 【Back】【Close 】【Print】【Add to favorite 】
-
Health and Chemical more >
-
Hot Products
- 123-77-3 Azodicarbonamide
- 4795-29-3 2-Tetrahydrofurfurylamine
- 3303-84-2 Boc-beta-alanine
- 1074-12-0 PHENYLGLYOXAL
- 116-31-4 trans-Retinal
- 2743-38-6 Dibenzoyl-L-tartaric acid
- 222400-29-5 PEAPROTEIN
- 9005-67-8 Tween60
- 63148-69-6 ALKYD RESIN
- 2916-68-9 2-(Trimethylsilyl)ethanol
- 33704-61-9 CASHMERAN
- 8062-15-5 Lignosulfonic acid