- Production of Labetalol hydrochloride
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hydrochloride (CAS NO.: ), with its systematic name of , 2-hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-, monohydrochloride, could be produced through many synthetic methods.
Following is one of the synthesis routes: 5-Bromoacetylsalicylamide (I) with N-benzyl-N-(1-methyl-3-phenylpropyl)amine (II) is condensed in the presence of refluxing butanone to produce 5-(N-benzyl-N-(1-methyl-3-phenylpropyl) glycyl)salicylamide hydrochloride (III), m.p. 139-141 C, and next the yielding compound is reduced with H2 over Pt-Pd/C in ethanol.
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