Tiospirone hydrochloride (CAS NO.: ), with its systematic name of 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-, monohydrochloride, could be produced through many synthetic methods.

Following is one of the synthesis routes:
The dicarboxylic acid (I) could react with chloride in hot toluene to produce the di-acid chloride (II). Treatment of (II) with Cl₂ in CH₂Cl₂ gives the sulfenyl chloride (III), which upon reaction with NH₄OH affords the benzisothiazole (IV). Chlorination of (IV) in heat POCl₃ yields the chlorobenzisothiazole (V). Reaction of (V) and piperazine (VI) in excess molten pipeazine gives the monosubstituted piperazine (VII). Reaction of (VII) with the dibromide (VIII) in refluxing ethanol yields the spiroquaternary (IX). At last, BMY-13859-1 is obtained by treatment of (IX) with the glutarimide (X) in refluxing xylene followed by treatment with HCl in isopropanol.