- Production Method of Dantrolene sodium
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sodium (CAS NO.: ), with other name of Hydantoin, 1-((5-(p-nitrophenyl)furfurylidene)amino)-, sodium salt, could be produced through many synthetic methods.
Following is one of the synthesis routes:
Diazotization of 4-nitroaniline (I), followed by copper-catalyzed coupling of the resultant diazonium salt (II) with (III) leads to 5-(p-nitrophenyl)-2-furancarboxaldehyde (IV) (1). Cyclization of semicarbazideacetic acid (V) by heating in aqueous sulfuric acid leads to 1-aminohydantoin (VI) (2). This is then condensed with aldehyde (IV) to furnish the furfurylidene aminohydantoin (VII) (1, 2). Treatment of (VII) with sodium methoxide gives rise to the corresponding sodium salt (1).
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