- Synthesis of Brequinar sodium
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sodium (CAS NO.: ), with other name of 4-carboxylic acid, 6-fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-, sodium salt, could be produced through many synthetic methods.
Following is one of the synthesis routes: By cyclization of 5-fluoroisatin (I) with 4-(2-fluorophenyl)- propiophenone (II) in the presence of NaOH in refluxing ethanol - water.
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