- Production Method of D 15413
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D 15413 (CAS NO.: ), with its systematic name of Indol-6-ol, 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-, could be produced through many synthetic methods.
Following is one of the synthesis routes: Diastereomeric 1,2-bis(2,6-dichloro-4-methoxyphenyl)- 1-2-bis(ethylamino)ethane (III) is synthesized by reductive dimerization of 2,6-dichloro-4-methoxybenzaldehyde ethylimine (I) using 1,1,2,2-tetraphenylethanediol (II). Separation of the diastereomers is accomplished by crystallization. Thermolysis of (III) at 215 C affords 4-chloro-2-(2,6-dichloro-4-methoxyphenyl)-1-ethyl-6-methoxyindole (IV). The free phenolic compound D-15413 is obtained by ether cleavage with BBr3 and recrystallization from aqueous MeOH.
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