Mofezolac (CAS NO.: ), with its systematic name of 3,4-bis(p-Methoxyphenyl)-5-isoxazoleacetic acid, could be produced through many synthetic methods.

Following is one of the synthesis routes:
Desoxyanisoin (I) reacts with hydroxylamine in methanol to produce the corresponding oxime (I), and then the yielding compound is cyclized with ethyl acetate (III) in the presence of n-butyllithium in THF yielding 3,4-di(4-methoxyphenyl)-5-methylisoxazole (IV). Lastly, this compound is condensed with CO₂ by means of n-butyllithium in THF.