- Synthesis of Anipamil
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Anipamil (CAS NO.: ), with other name of 2-[3-[N-[2-(3-Methoxyphenyl)ethyl]-N-methylamino]propyl]-2-(3-methoxyphenyl)tetradecanitrile, could be produced through the following synthetic routes.
The reaction routes are as below:

By condensation of 2-(3-methoxyphenyl)tetradecanenitrile (I) [prepared by alkylation of 3-methoxyphenylacetonitrile (III) with 1-bromoundecane (IV) with 1-chloro-4-methyl-6-(3-methoxyphenyl)-4-azahexane (II) (prepared by alkylation of N-methyl-[2-(3-methoxyphenyl)ethylamine (VI) with 1-bromo-3-chloropropane (V)) by means of sodium amide in refluxing toluene.
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