Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
Chlorpropham |
EINECS | 202-925-7 |
CAS No. | 101-21-3 | Density | 1.226 g/cm3 |
PSA | 38.33000 | LogP | 3.36990 |
Solubility | 0.009 g/100 ml very poor in water | Melting Point |
41 °C |
Formula | C10H12ClNO2 | Boiling Point | 251.1 °C at 760 mmHg |
Molecular Weight | 213.664 | Flash Point | 105.7 °C |
Transport Information | UN 3077 9/PG 3 | Appearance | beige to brown solid |
Safety | Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Human mutation data reported. An herbicide. When heated to decomposition it emits highly toxic fumes of Cl−, NOx, and phosgene. | Risk Codes | 22-51/53-36-20/21/22-11 |
Molecular Structure | Hazard Symbols | Xn,N,F | |
Synonyms |
IsopropylN-(3-chlorophenyl)carbamate;Isopropyl N-(m-chlorophenyl)carbamate;Isopropylm-chlorocarbanilate;Keim-Stop;Liro CIPC;Metoxon;Mirvale;NSC 29466;Nexoval;Preventol;Preventol 56;Triherbicide CIPC;Y 3;m-Chlorocarbanilicacid isopropyl ester;Carbamic acid,N-(3-chlorophenyl)-, 1-methylethyl ester;Carbamicacid, (3-chlorophenyl)-, 1-methylethyl ester (9CI);Carbanilic acid, m-chloro-,isopropyl ester (6CI,7CI,8CI);Bud Nip;Bygran;CI-IPC;CIPC;Chlor IFC;ChlorIFK;Chlor IPC;Chloro-IPC;Cl-IFK;Elbanil;Furloe;Furloe 3EC;IPCPC;Isopropyl 3-chlorocarbanilate; |
Article Data | 18 |
1-azido-3-chlorobenzene
carbon monoxide
isopropyl alcohol
CHLORPROPHAM
Conditions | Yield |
---|---|
With triethylamine; palladium dichloride In N,N-dimethyl acetamide at 70℃; under 760.051 Torr; for 24h; Schlenk technique; | 94% |
potassium cyanate
1-bromo-3-chlorobenzene
isopropyl alcohol
CHLORPROPHAM
Conditions | Yield |
---|---|
With copper(l) iodide; 2-(2,6-dimethylphenyl-amino)-2-oxoacetic acid potassium salt at 110℃; for 24h; Inert atmosphere; | 85% |
Conditions | Yield |
---|---|
With copper diacetate at 20℃; for 1h; Inert atmosphere; | 81% |
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; 2-((2-methylnaphthalen-1-yl)amino)-2-oxoacetic acid at 100℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube; | 67% |
Conditions | Yield |
---|---|
With Oxone; chloro(1,5-cyclooctadiene)rhodium(I) dimer In toluene at 20 - 100℃; Schlenk technique; Cooling with liquid nitrogen; | 50% |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / water / 0 °C 1.2: 0.17 h 2.1: palladium dichloride; triethylamine / N,N-dimethyl acetamide / 24 h / 70 °C / 760.05 Torr / Schlenk technique View Scheme |
Conditions | Yield |
---|---|
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 24h; Inert atmosphere; | 92% |
Conditions | Yield |
---|---|
In water at 20℃; Kinetics; Quantum yield; Decomposition; Oxidation; UV-irradiation; | 70% |
CHLORPROPHAM
isopropyl chloroformate
(3-chloro-phenyl)-μ-imido-dicarbonic acid diisopropyl ester
formaldehyd
CHLORPROPHAM
Isopropyl-N-chloromethyl-N-(3-chlorophenyl)-carbamate
Conditions | Yield |
---|---|
With thionyl chloride |
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 12 , 1976,p. 55.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Basic Information of Chlorpropham:
The Chlorpropham, with the CAS registry number 101-21-3, is also known as Isopropyl N-(3-chlorophenyl)carbamate; Isopropyl 3-chlorocarbanilate. It belongs to the product categories of Amides;Building Blocks;C8 to C20+;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks.This chemical's molecular formula is C10H12ClNO2 and molecular weight is 213.66.Its EINECS number is 202-925-7. What's more,Its systematic name is Chlorpropham. It is a carbamate that is used as an herbicide and as a plant growth regulator.It is beige to brown chunky solid,and it is Stable. Incompatible with strong acids, strong bases, strong oxidizing agents. Chlorpropham is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.
Physical properties about Chlorpropham are:
(1)ACD/LogP: 3.569; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.57; (4)ACD/LogD (pH 7.4): 3.57; (5)ACD/BCF (pH 5.5): 303.84; (6)ACD/BCF (pH 7.4): 303.84; (7)ACD/KOC (pH 5.5): 2082.96; (8)ACD/KOC (pH 7.4): 2082.96; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.561; (13)Molar Refractivity: 56.389 cm3; (14)Molar Volume: 174.219 cm3; (15)Surface Tension: 41.9949989318848 dyne/cm; (16)Density: 1.226 g/cm3; (17)Flash Point: 105.653 °C; (18)Enthalpy of Vaporization: 48.838 kJ/mol; (19)Boiling Point: 251.086 °C at 760 mmHg; (20)Vapour Pressure: 0.0209999997168779 mmHg at 25°C;
Safety Information of Chlorpropham:
The Chlorpropham is highly Flammable. It is harmful by inhalation, in contact with skin and if swallowed ,and irritating to the eyes And it is toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.When you use it, wear suitable protective clothing and gloves .Avoid release to the environment. Refer to special instructions safety data sheet.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES:Clc1cc(NC(=O)OC(C)C)ccc1;
(2)Std. InChI:InChI=1S/C10H12ClNO2/c1-7(2)14-10(13)12-9-5-3-4-8(11)6-9/h3-7H,1-2H3,(H,12,13);
(3)Std. InChIKey:CWJSHJJYOPWUGX-UHFFFAOYSA-N.
The toxicity data of Chlorpropham as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
duck | LD50 | unreported | > 2gm/kg (2000mg/kg) | Farm Chemicals Handbook. Vol. -, Pg. C73, 1991. | |
mammal (species unspecified) | LD50 | unreported | 3gm/kg (3000mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 200, 1971. | |
mouse | LD50 | intraperitoneal | 2600mg/kg (2600mg/kg) | Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 175, Pg. 496, 1981. | |
mouse | LD50 | oral | 3650mg/kg (3650mg/kg) | Food Additives and Contaminants. Vol. 16, Pg. 173, 1999. | |
rabbit | LD50 | oral | 5gm/kg (5000mg/kg) | Pharmacological Reviews. Vol. 14, Pg. 225, 1962. | |
rat | LD50 | intraperitoneal | 700mg/kg (700mg/kg) | Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 175, Pg. 496, 1981. | |
rat | LD50 | oral | 1200mg/kg (1200mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Archives of Environmental Health. Vol. 19, Pg. 621, 1969. |
rat | LD50 | unreported | 3350mg/kg (3350mg/kg) | Environmental Quality and Safety, Supplement. Vol. 3, Pg. 618, 1975. |