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Basic Information
| CAS No.: | 108-23-6 |
|---|---|
| Name: | Isopropyl chloroformate |
| Article Data: | 20 |
| Molecular Structure: | |
|
|
|
| Formula: | C4H7ClO2 |
| Molecular Weight: | 122.551 |
| Synonyms: | Formicacid, chloro-, isopropyl ester (6CI,7CI,8CI);1-Methylethyl chloroformate;2-Propyl chloroformate;Chloroformic acid isopropyl ester;Isopropoxycarbonylchloride;Isopropyl carbonochloridate;Isopropyl chlorocarbonate;Isopropylchloroformate; |
| EINECS: | 203-563-2 |
| Density: | 1.116 g/cm3 |
| Melting Point: | -81oC |
| Boiling Point: | 108.3 °C at 760 mmHg |
| Flash Point: | 25 °C |
| Appearance: | clear colorless volatile liquid |
| Hazard Symbols: |
 F, C
|
| Risk Codes: | 11-34-48/20-63-65-67 |
| Safety: | 26-36/37/39-45-62 |
| Transport Information: | UN 3286 3/PG 2 |
| PSA: | 26.30000 |
| LogP: | 1.77020 |
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Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| In neat (no solvent, gas phase) 150°C; | 55% |
| at 150℃; in der Dampfphase; |
- 67-63-0
isopropyl alcohol
- 503-38-8
trichloromethyl chloroformate
A
- 7647-01-0
hydrogenchloride
B
- 75-44-5
phosgene
C
- 108-23-6
isopropyl chloroformate
...Expand
Conditions
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at 0 - 20℃; for 0.5h; | |
| With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Ice bath; Inert atmosphere; |
Conditions
| Conditions | Yield |
|---|---|
| With chlorine Kinetics; Mechanism; Photolysis; Inert atmosphere; |
- 27687-12-3
(1r,4r)-4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid
- 108-23-6
isopropyl chloroformate
Conditions
| Conditions | Yield |
|---|---|
| With 4-methyl-morpholine In tetrahydrofuran at -20℃; for 1h; | 100% |
- 108-23-6
isopropyl chloroformate
- 393792-04-6
(2S,4R)-2-azidomethyl-4-tritylsulfanylpyrrolidine
- 844476-72-8
(2S,4R)-2-azidomethyl-4-tritylsulfanylpyrrolidine-1-carboxylic acid isopropyl ester
Conditions
| Conditions | Yield |
|---|---|
| With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 48h; | 100% |
- 620-08-6
4-methoxypyridine
- 108-23-6
isopropyl chloroformate
- 1730-25-2
allylmagnesium bromide
- 1003847-45-7
C12H17NO3
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 4-methoxypyridine; isopropyl chloroformate; allylmagnesium bromide In tetrahydrofuran at -40℃; Stage #2: Acidic aqueous solution; | 100% |
...Expand
- 1160834-05-8
2-(2-chloro-5-[1,4]diazepan-1-yl-phenyl)-1H-benzoimidazole
- 108-23-6
isopropyl chloroformate
- 108-00-9
N,N-dimethylethylenediamine
- 1160829-74-2
4-[3-(1H-benzoimidazol-2-yl)-4-chloro-phenyl]-[1,4]diazepane-1-carboxylic acid (2-dimethylamino-ethyl)-amide
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: isopropyl chloroformate; N,N-dimethylethylenediamine With triethylamine In 1,4-dioxane at 20℃; for 1h; Stage #2: 2-(2-chloro-5-[1,4]diazepan-1-yl-phenyl)-1H-benzoimidazole In 1,4-dioxane at 150℃; for 1h; Microwave irradiation; | 100% |
...Expand
- 6117-80-2
1,4-butenediol
- 108-23-6
isopropyl chloroformate
- 783368-59-2
(Z)-1,4-bis(i-propoxycarbonyloxy)-2-butene
Conditions
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane at 5 - 20℃; for 4h; Inert atmosphere; | 100% |
- 120641-01-2
octahydro-[1]pyrindin-4-one; hydrochloride
- 108-23-6
isopropyl chloroformate
- 1246734-21-3
C12H19NO3
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydrogencarbonate In tetrahydrofuran; water; toluene at 0 - 20℃; | 100% |
Raw Materials
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Isopropyl chloroformate
Chemistry
Product Name: Isopropyl chloroformate
The MF of Isopropyl chloroformate (108-23-6) is C4H7ClO2.
The MW of Isopropyl chloroformate (108-23-6) is 122.55.
Synonyms: 1-methylethylchloroformate ; carbonochlorideacid , 1-methylethylester ; isopropylchloroformatesolution ; Carbonochloridicacid , 1-methylester ; chlorocarbonicacidisopropylester ; chloro-formicaciisopropylester ; isopropylchloromethanoate ; isopropylesterkyselinychlormravenci
Product Categories: CHLOROFORMATES;Acid Halides;Carbonyl Compounds;Organic Building Blocks
EINECS: 203-563-2
Flash Point: 25 °C
Boiling Point: 108.3 °C
density: 0.892 g/mL at 25 °C
refractive index: n20/D 1.485(lit.)
storage temp: 2-8°C
The MF of Isopropyl chloroformate (108-23-6) is C4H7ClO2.
The MW of Isopropyl chloroformate (108-23-6) is 122.55.
Synonyms: 1-methylethylchloroformate ; carbonochlorideacid , 1-methylethylester ; isopropylchloroformatesolution ; Carbonochloridicacid , 1-methylester ; chlorocarbonicacidisopropylester ; chloro-formicaciisopropylester ; isopropylchloromethanoate ; isopropylesterkyselinychlormravenci
Product Categories: CHLOROFORMATES;Acid Halides;Carbonyl Compounds;Organic Building Blocks
EINECS: 203-563-2
Flash Point: 25 °C
Boiling Point: 108.3 °C
density: 0.892 g/mL at 25 °C
refractive index: n20/D 1.485(lit.)
storage temp: 2-8°C
Uses
Isopropyl chloroformate (108-23-6) is used as PVC resin, when used as a polymerization initiator, but also used as pesticide intermediates, ore flotation agents.
Toxicity Data With Reference
| 1. | skn-rbt 500 mg | IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. 6 (1967),1. | ||
| 2. | eye-rbt 500 mg SEV | IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. 6 (1967),1. | ||
| 3. | orl-rat LD50:1070 mg/kg | IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. 6 (1967),1. | ||
| 4. | ihl-rat LCLo:200 ppm/5H | BJIMAG British Journal of Industrial Medicine. 27 (1970),1. | ||
| 5. | orl-mus LD50:178 mg/kg | 37ASAA Kirk-Othmer Encyclopedia of Chemical Technology. 4 (1978),758. | ||
| 6. | ihl-mus LD50:299 ppm/1H | 37ASAA Kirk-Othmer Encyclopedia of Chemical Technology. 4 (1978),758. | ||
| 7. | skn-mus LD50:12 mg/kg | 37ASAA Kirk-Othmer Encyclopedia of Chemical Technology. 4 (1978),758. | ||
| 8. | skn-rbt LD50:11,300 mg/kg | IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. 6 (1967),1. |
Consensus Reports
EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.
Safety Profile
A poison by skin contact and ingestion. Moderately toxic by inhalation. Ingestion of even small amounts can be fatal. A skin and severe eye irritant. Inhalation of a small amount can cause immediate lachrymation, coughing, choking, and respiratory distress. Death may result from pulmonary edema which may not appear for several hours after exposure. A dangerous fire and moderate explosion hazard when exposed to heat, spark, or flame. Self-reactive. Iron salts may catalyze a potentially explosive thermal decomposition. Incompatible with water, iron, metal salts, acids, alkalies, amines, alcohols. Stable under refrigeration below 20°, but one reference (1973) reports that it has exploded while stored in a refrigerator. Present-day formulations appear to be more stable. Temperatures above 20° can cause decomposition. When heated to decomposition it emits acrid smoke and fumes.
Safety information of Isopropyl chloroformate (108-23-6):
Hazard Codes
F,
C
Risk Statements 11-34-48/20-63-65-67
R11: Highly Flammable
R34: Causes burns
R48/20: Harmful: danger of serious damage to health by prolonged exposure through inhalation
R63: Possible risk of harm to the unborn child
R65: Harmful: May cause lung damage if swallowed
R67: Vapors may cause drowsiness and dizziness
Safety Statements 26-36/37/39-45-62
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S62: If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label
RIDADR UN 3286 3/PG 2
WGK Germany 2
RTECS LQ6475000
F 10-19
HazardClass 6.1(a)
PackingGroup I
Safety information of Isopropyl chloroformate (108-23-6):
Hazard Codes
F,C Risk Statements 11-34-48/20-63-65-67
R11: Highly Flammable
R34: Causes burns
R48/20: Harmful: danger of serious damage to health by prolonged exposure through inhalation
R63: Possible risk of harm to the unborn child
R65: Harmful: May cause lung damage if swallowed
R67: Vapors may cause drowsiness and dizziness
Safety Statements 26-36/37/39-45-62
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S62: If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label
RIDADR UN 3286 3/PG 2
WGK Germany 2
RTECS LQ6475000
F 10-19
HazardClass 6.1(a)
PackingGroup I
Standards and Recommendations
DOT Classification: 3; Label: Flammable Liquid, Corrosive, Poison
Specification
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
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