|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
- Name Clobetasol propionate
- EINECS246-634-3
- CAS No. 25122-46-7
- Density1.28 g/cm3
- PSA80.67000
- LogP4.10310
- SolubilityN/A
- Melting Point195.5-197 °C
- FormulaC25H32ClFO5
- Boiling Point569 °C at 760 mmHg
- Molecular Weight466.977
- Flash Point297.9 °C
- Transport InformationN/A
- AppearanceWhite crystalline powder
- Safety26-36
- Risk Codes36/37/38
- Molecular Structure
- Hazard Symbols
Xi - SynonymsXi
- Article Data8
Clobetasol propionate Synthetic route
- 25122-46-7
clobetasol-17-propionate
| Conditions | Yield |
|---|---|
| With hydrogen fluoride; potassium hydroxide In water; acetone at -40 - -30℃; for 6h; Temperature; | 95% |
- 25122-46-7
clobetasol-17-propionate
| Conditions | Yield |
|---|---|
| With hydrogen fluoride In tetrahydrofuran; water at -5 - 0℃; Solvent; | 94.3% |
| With hydrogen fluoride In chloroform; water at -40℃; | 84% |
- 1062-09-5
Betamethasone 17α,21-ethyl orthopropanoate
- 25122-46-7
clobetasol-17-propionate
| Conditions | Yield |
|---|---|
| With chloro-trimethyl-silane In N,N-dimethyl-formamide |
- 25122-46-7
clobetasol-17-propionate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1.1: sodium hydroxide / -5 - 5 °C 1.2: 20 °C / Darkness 1.3: 20 °C 2.1: toluene-4-sulfonic acid / dichloromethane / 20 °C 3.1: tert.-butylhydroperoxide; N-benzyl-trimethylammonium hydroxide / tetrahydrofuran / 20 °C 4.1: hydrogen bromide / dichloromethane / 20 °C 4.2: Raney nickel / 20 °C 5.1: triethylamine; dmap / chloroform / 50 °C 6.1: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C 7.1: hydrogen fluoride / chloroform; water / -40 °C View Scheme |
- 25122-46-7
clobetasol-17-propionate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1.1: toluene-4-sulfonic acid / dichloromethane / 20 °C 2.1: tert.-butylhydroperoxide; N-benzyl-trimethylammonium hydroxide / tetrahydrofuran / 20 °C 3.1: hydrogen bromide / dichloromethane / 20 °C 3.2: Raney nickel / 20 °C 4.1: triethylamine; dmap / chloroform / 50 °C 5.1: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C 6.1: hydrogen fluoride / chloroform; water / -40 °C View Scheme |
- 25122-46-7
clobetasol-17-propionate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: tert.-butylhydroperoxide; N-benzyl-trimethylammonium hydroxide / tetrahydrofuran / 20 °C 2.1: hydrogen bromide / dichloromethane / 20 °C 2.2: Raney nickel / 20 °C 3.1: triethylamine; dmap / chloroform / 50 °C 4.1: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C 5.1: hydrogen fluoride / chloroform; water / -40 °C View Scheme |
- 25122-46-7
clobetasol-17-propionate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: hydrogen bromide / dichloromethane / 20 °C 1.2: Raney nickel / 20 °C 2.1: triethylamine; dmap / chloroform / 50 °C 3.1: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C 4.1: hydrogen fluoride / chloroform; water / -40 °C View Scheme |
- 116846-77-6
21-Chloro-17α-hydroxy-16β-methylpregna-1,4,9(11)-triene-3,20-dione
- 25122-46-7
clobetasol-17-propionate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: triethylamine; dmap / chloroform / 50 °C 2: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C 3: hydrogen fluoride / chloroform; water / -40 °C View Scheme |
- 25122-46-7
clobetasol-17-propionate
- 80042-35-9
21-chloro-9α-fluoro-16β-methyl-11β,17α-dihydroxy-5β-pregnane-3,20-dione 17-propionate
| Conditions | Yield |
|---|---|
| palladium In 4,4-dichlorobutan-2-one; ethyl acetate | |
| palladium In 4,4-dichlorobutan-2-one; ethyl acetate |
Clobetasol propionate Chemical Properties
.jpg)
IUPAC Name: [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Molecular Weight: 466.969983 [g/mol]
Molecular Formula: C25H32ClFO5
XLogP3: 3.8
H-Bond Donor: 1
H-Bond Acceptor: 6
EINECS: 246-634-3
Product Categories: Organics; Intermediates & Fine Chemicals; Pharmaceuticals
Index of Refraction: 1.56
Molar Refractivity: 117.75 cm3
Molar Volume: 364.1 cm3
Surface Tension: 48.9 dyne/cm
Density: 1.28 g/cm3
Flash Point: 297.9 °C
Enthalpy of Vaporization: 98.07 kJ/mol
Boiling Point: 569 °C at 760 mmHg
Vapour Pressure: 2.58E-15 mmHg at 25 °C
Water Solubility: 3.860 mg/L at 25 °C
Appearance: White Crystalline Powder
Melting Point: 195.5-197 °C
Classification Code of Clobetasol propionate (CAS NO.25122-46-7): Anti-inflammatory; Drug / Therapeutic Agent; Hormone; Reproductive Effect
Clobetasol propionate Uses
Clobetasol propionate (CAS NO.25122-46-7) is used for the treatment of various skin disorders including eczema, psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus (auto immune skin nodules).
Clobetasol propionate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 118mg/kg (118mg/kg) | Drugs in Japan Vol. 6, Pg. 241, 1982. | |
| mouse | LD50 | oral | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. 6, Pg. 241, 1982. | |
| mouse | LD50 | subcutaneous | 81700ug/kg (81.7mg/kg) | Drugs in Japan Vol. 6, Pg. 241, 1982. | |
| rat | LD50 | intraperitoneal | 351mg/kg (351mg/kg) | Drugs in Japan Vol. 6, Pg. 241, 1982. | |
| rat | LD50 | oral | > 3gm/kg (3000mg/kg) | Drugs in Japan Vol. 6, Pg. 241, 1982. | |
| rat | LD50 | subcutaneous | 366mg/kg (366mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 1066, 1978. |
Clobetasol propionate Safety Profile
Hazard Codes:Xi 
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
Poison by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F− and Cl−.
Clobetasol propionate Specification
Clobetasol propionate (CAS NO.25122-46-7), its Synonyms are 21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione (11beta,16beta)- ; 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate ; Butavate ; Clobesol ; Clobetasol 17-propionate ; Clobex ; Cormax ; Dermoval ; Dermovate ; Dermoxinale ; Embeline ; Embeline E ; Olux-E ; Temovate ; Temovate E ; Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-methyl-, 17-propionate ; Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11beta,16beta)- .
What can I do for you?
Get Best Price
- Clobetasol
- Clobetasol propionate
- 25122-57-0Pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16b)-
- 2512-29-0C.I. Pigment Yellow 1
- 25123-05-1Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester
- 25125-21-73-Cyclopentene-1-methanol
- 25125-46-6Tetradecaamminedi-mu-oxotriruthenium(6+) hexachloride
- 25126-32-3Cholecystokinin-8(swine) (9CI)
- 25126-76-5Androstane-3,17-diol
- 25127-29-15H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline,6,7,7a,8-tetrahydro-9,10-dimethoxy-7-methyl-, (7R)-
- 25128-35-21H-Indole-7-carboxylicacid, 2,3-dihydro-2,3-dioxo-
- 251293-28-4L-Valine, L-a-glutamyl-L-threonyl-L-prolyl-L-a-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-,cyclic (5®10)-disulfide
Hot Products
- 145-13-1Pregnenolone
- 6306-52-1L-Valine methyl ester hydrochloride
- 112068-01-6(S)-(-)-Alpha,alpha-Diphenyl-2-pyrrolidinemethanol
- 127-40-2Xanthophyll
- 693-98-12-Methylimidazole
- 7682-20-4Butanamide, 2-amino-,hydrochloride (1:1), (2S)-
- 1197-18-8Tranexamic acid
- 183322-18-14-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin