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Dimethyl disulfide

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Name

Dimethyl disulfide

EINECS 210-871-0
CAS No. 624-92-0 Density 1.052 g/cm3
PSA 50.60000 LogP 1.62740
Solubility <0.1 g/100 mL at 20 °C in water Melting Point -85 °C
Formula C2H6S2 Boiling Point 109.7 °C at 760 mmHg
Molecular Weight 94.2016 Flash Point 24.4 °C
Transport Information UN 2381 3/PG 2 Appearance colourless to yellow liquid
Safety 26-61-45-38-36/37/39-28A-16-60 Risk Codes 11-20/22-36-51/53-36/37/38-26-22
Molecular Structure Molecular Structure of 624-92-0 (Dimethyl disulfide) Hazard Symbols HarmfulXn,FlammableF, VeryT+, DangerousN
Synonyms

FEMA No. 3536;Disulfide,dimethyl;Methyl disulfide (8CI);Disulfide, dimethyl;Methyldisulfide;(Methyldithio)methane;Methyldithiomethane;Dimethyl disulphide;2,3-Dithiabutane;Sulfa-Hitech;

Article Data 190

Dimethyl disulfide Synthetic route

124-63-0

methanesulfonyl chloride

624-92-0

Dimethyldisulphide

Conditions
ConditionsYield
With trimethylsilyl iodide In 1,2-dichloro-ethane for 16h; Heating;100%
With sulfuric acid; sulfur dioxide; potassium iodide In water at 80℃; for 1h;92.9%
With tungsten(VI) chloride; sodium iodide In acetonitrile for 12h; Ambient temperature;90%
28925-45-3

S-methyl O-benzyl dithiocarbonate

A

624-92-0

Dimethyldisulphide

B

100-44-7

benzyl chloride

Conditions
ConditionsYield
With copper(l) chloride; copper dichloride In acetonitrile for 96h; Ambient temperature;A 100%
B 60%

9-methylsulfinyl-10-(methylthio)anthracene

A

624-92-0

Dimethyldisulphide

B

84-65-1

9,10-phenanthrenequinone

Conditions
ConditionsYield
Stage #1: 9-methylsulfinyl-10-(methylthio)anthracene With air; sulfuric acid In dichloromethane at 20℃; for 0.0833333h; Rearrangement;
Stage #2: With water; sodium hydrogencarbonate Hydrolysis;
A n/a
B 100%
74-93-1

methylthiol

624-92-0

Dimethyldisulphide

Conditions
ConditionsYield
Stage #1: methylthiol With sodium hydroxide at 51℃;
Stage #2: With oxygen at 55℃; under 4500.45 Torr; Temperature; Pressure; Reagent/catalyst;
97.6%
With Cu,Na-X zeolite; oxygen at 189.9℃; Product distribution; Mechanism; other catalysts; other temp.;
With air at 170 - 270℃;
33696-21-8

N,N-dimethylmethane sulfenamide

74-88-4

methyl iodide

A

624-92-0

Dimethyldisulphide

B

75-58-1

tertamethylammonium iodide

Conditions
ConditionsYield
In chloroform Product distribution; Ambient temperature; var. amino thioethers, var. electrophiles;A 96%
B 96%
629-45-8

dibutyl disulfide

1680-29-1

S-methyl decanethioate

A

624-92-0

Dimethyldisulphide

B

S-butyl decanethioate

Conditions
ConditionsYield
[RhCl(PPh3)] In 1,2-dichloro-benzene at 150℃; for 1.5h;A n/a
B 95%
67-56-1

methanol

74-93-1

methylthiol

A

75-15-0

carbon disulfide

B

624-92-0

Dimethyldisulphide

C

3658-80-8

dimethyltrisulfane

Conditions
ConditionsYield
Stage #1: methanol; methylthiol With hydrogen sulfide; aluminum oxide with 14percent by weight of potassium tungstate at 400℃;
Stage #2: With sulfur; N-cyclohexyl-cyclohexanamine
A n/a
B 94.9%
C n/a
53475-19-7

2,3-dimethyl-3-methylsulfanyl-3H-indole

A

91-55-4

2,3-dimethylindole

B

624-92-0

Dimethyldisulphide

Conditions
ConditionsYield
With mercaptoacetic acid In dichloromethane for 0.5h; Heating;A 93%
B n/a
With mercaptoacetic acid In dichloromethane for 0.5h; Mechanism; Heating;
69177-66-8

bis(2-methoxyethyl) disulfide

1680-29-1

S-methyl decanethioate

A

1020261-42-0

S-(2-methoxy)ethyl decanethioate

B

624-92-0

Dimethyldisulphide

Conditions
ConditionsYield
[RhCl(PPh3)] In 1,2-dichloro-benzene at 150℃; for 1.5h;A 93%
B n/a
1680-29-1

S-methyl decanethioate

67385-10-8

di-tert-butyl(disulfanediylbis(ethane-2,1-diyl))dicarbamate

A

1020261-43-1

S-[2-(t-butoxycarbonyl)amino]ethyl decanethioate

B

624-92-0

Dimethyldisulphide

Conditions
ConditionsYield
[RhCl(PPh3)] In 1,2-dichloro-benzene at 150℃; for 1.5h;A 92%
B n/a

Dimethyl disulfide Specification

The IUPAC name of Dimethyl disulfide is (methyldisulfanyl)methane. With the CAS registry number 624-92-0, it is also named as Methyl disulfide. The product's category is Sulfide Flavor. Besides, it is colourless to yellow liquid with a very unpleasant smell, which should be stored in sealed containers in a cool, dry place away from oxidizing agents and reducing agents. It is stable, but incompatible with strong bases, strong oxidizing agents, strong reducing agents. In addition, its molecular formula is C2H6S2 and molecular weight is 94.19.

The other characteristics of this product can be summarized as: (1)EINECS: 210-871-0; (2)ACD/LogP: 1.77; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 1.77; (5)ACD/LogD (pH 7.4): 1.77; (6)ACD/BCF (pH 5.5): 13.04; (7)ACD/BCF (pH 7.4): 13.04; (8)ACD/KOC (pH 5.5): 218.72; (9)ACD/KOC (pH 7.4): 218.72; (10)#H bond acceptors: 0; (11)#H bond donors: 0; (12)#Freely Rotating Bonds: 1; (13)Index of Refraction: 1.522; (14)Molar Refractivity: 27.3 cm3; (15)Molar Volume: 89.4 cm3; (16)Surface Tension: 32.1 dyne/cm; (17)Density: 1.052 g/cm3; (18)Flash Point: 24.4 °C; (19)Melting Point: -85 °C; (20)Water Solubility: <0.1 g/100 mL at 20 °C; (21)Enthalpy of Vaporization: 33.78 kJ/mol; (22)Boiling Point: 109.7 °C at 760 mmHg; (23)Vapour Pressure: 28.7 mmHg at 25 °C.

Preparation of Dimethyl disulfide: this chemical can be prepared by the reaction of Dimethyl sulfate with Disodium disulfide.
Na2S+S→Na2S2
Na2S2+(CH3)2SO4→CH3SSCH3+Na2SO4

Uses of Dimethyl disulfide: this chemical is used as an intermediate of solvent and pesticide. It is also used as additive of fuel and lubricant. Additionally, it can be used as cooking inhibitor in ethylene furnace and refining equipment. The product can be used in the preparation of food flavors. Similarly, it can react with Diethyldisulfane to get Ethyl-methyl-disulfane.



This reaction needs NO, air and CD3CN at temperature of 20 °C for 1 hour. The yield is 49 %.

When you are using this chemical, please be cautious about it as the following: it is highly Flammable. Please keep away from sources of ignition. It is also harmful and very toxic by inhalation and if swallowed. And it is irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Moreover, you should wear suitable protective clothing, gloves and eye/face protection. After contact with skin, wash immediately with plenty of soap-suds. And in case of insufficient ventilation, wear suitable respiratory equipment. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible). Additionally, it is toxic to aquatic organisms that may cause long-term adverse effects in the aquatic environment. Please avoid release to the environment. Refer to special instructions safety data sheet. This material and its container must be disposed of as hazardous waste.

People can use the following data to convert to the molecule structure.
(1)SMILES: S(SC)C
(2)InChI: InChI=1/C2H6S2/c1-3-4-2/h1-2H3
(3)InChIKey: WQOXQRCZOLPYPM-UHFFFAOYAV

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 138mg/kg (138mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(6), Pg. 46, 1972.
mouse LC50 inhalation 12300ug/m3/2H (12.3mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(6), Pg. 46, 1972.
rat LC50 inhalation 15850ug/m3/2H (15.85mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(6), Pg. 46, 1972.

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