Bioorganic and Medicinal Chemistry Letters p. 2244 - 2251 (2011)
Update date:2022-09-26
Topics:
Venier, Olivier
Pascal, Cécile
Braun, Alain
Namane, Claudie
Mougenot, Patrick
Crespin, Olivier
Pacquet, Franois
Mougenot, Cécile
Monseau, Catherine
Onofri, Bénédicte
Dadji-Fa?hun, Rommel
Leger, Céline
Ben-Hassine, Majdi
Van-Pham, Thao
Ragot, Jean-Luc
Philippo, Christophe
Güssregen, Stefan
Engel, Christian
Farjot, Géraldine
Noah, Lionel
Maniani, Karima
Nicola?, Eric
A High Throughput Screening campaign allowed the identification of a novel class of ureas as 11β-HSD1 inhibitors. Rational chemical optimization provided potent and selective inhibitors of both human and murine 11β-HSD1 with an appropriate ADME profile an
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