SYNTHESIS OF NOVEL 1,4-, 3,4-, AND 4,5-DIHYDROPYRIMIDINES: FIRST SUCCESSFUL POCl3 CHLORINATION AND REGIOSELECTIVE ALKOXYCARBONYLATION

DOI: 10.1016/S0040-4039(00)87813-2

Source and publish data:

Tetrahedron Letters p. 6377 - 6380 (1986)

Update date:2022-08-05

Topics:

Authors:

Cho, Hidetsura

Ohnaka, Yoshiko

Hayashimatsu, Mariko

Ueda, Masaru

Shima, Keiyuu

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Article abstract of DOI:10.1016/S0040-4039(00)87813-2

Chlorination of 5,6-dihydropyrimidine-4-(3H)-one derivatives (1) with POCl3 gave 1,4(3,4)-dihydropyrimidines (3), whose alkoxycarbonylation (ClCOOR-Et3N or NaH) afforded regioselectively novel compounds (4).A new Pummerer type rearrangement of compound (1

Full text of DOI:10.1016/S0040-4039(00)87813-2

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