DIRECT INTRODUCTION OF ACYL AND ETHOXYCARBONYL GROUPS INTO PYRIMIDINE RING THROUGH THE TRIMETHYLSTANNYL DERIVATIVES

Article abstract of DOI:10.3987/COM-95-7055

The reactions of acylformyl chlorides with 2- and 4-trimethylstannylpyrimidine derivatives proceeded more smoothly than those of acyl chlorides giving the corresponding 2- and 4-acylpyrimidines.Employing ethyl chloroglyoxylate instead of the acylating agent yielded the ethoxycarbonylpyrimidines.Similarly, the stepwise acylation and ethoxycarbonylation of bis(trimethylstannyl)pyrimidines provided pyrimidines having two different carbon functional groups.