Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation

Article abstract of DOI:10.1021/jm701170f

In our quest for HIV-1 protease inhibitors that are not affected by the V82A resistance mutation, we have synthesized and tested a second generation set of C₂-symmetric HIV-1 protease inhibitors that contain a cyclohexane group at P1 and/or P1′