Bioorganic and Medicinal Chemistry Letters p. 619 - 623 (2008)
Update date:2022-08-04
Topics:
Nie, Zhe
Perretta, Carin
Erickson, Philip
Margosiak, Stephen
Lu, Jia
Averill, April
Almassy, Robert
Chu, Shaosong
A series of macrocyclic derivatives has been designed and synthesized based on the X-ray co-crystal structures of pyrazolo[1,5-a] [1,3,5]triazines with corn CK2 (cCK2) protein. Bioassays demonstrated that these macrocyclic pyrazolo[1,5-a] [1,3,5]triazine
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