Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes

DOI: 10.1021/ja074138u

Source and publish data:

Journal of the American Chemical Society p. 2184 - 2194 (2008)

Update date:2022-08-04

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Authors:

Salisbury, Cleo M.

Cravatt, Benjamin F.

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Article abstract of DOI:10.1021/ja074138u

Histone deacetylases (HDACs) are key enzymatic regulators of the epigenome and serve as promising targets for anticancer therapeutics. Recently, we developed a photoreactive "clickable" probe, SAHA-BPyne, to report on HDAC activity and complex formation i

Full text of DOI:10.1021/ja074138u

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