Allergenic α-Methylene-γ-butyrolactones. Study of the Capacity of β-Acetoxy- and β-Hydroxy-α-methylene-γ-butyrolactones To Induce Allergic Contact Dermatitis in Guinea Pigs

Article abstract of DOI:10.1021/jm00155a046

(+/-)-Tulipalin B was prepared in six steps from phenyl sulfide and ethyl 2-bromopropionate.The sensitizing power in the skin of (+/-)-tulipalin A (1a) and B (1b) and of the β-acetoxy derivatives (1c) was studied.All are able to induce allergic contact de