Pd(II)-Catalyzed Direct Sulfonylation of Benzylamines Using Sodium Sulfinates

Article abstract of DOI:10.1021/acs.joc.8b03098

A Pd(II)-catalyzed direct sulfonylation of benzylamines with sodium sulfinates using a removable bidentate directing group is illustrated. The transformation is highly regioselective and tolerates wide functional groups. The mechanistic study reveals that radical species are involved in this reaction. This method delivers a direct synthetic strategy to obtain highly functionalized sulfonylated benzylamines.

Full text of DOI:10.1021/acs.joc.8b03098

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Article
Pd(II)-Catalyzed Direct Sulfonylation of
Benzylamines using Sodium Sulfinates
Ujjwal Karmakar, and Rajarshi Samanta
J. Org. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.joc.8b03098 • Publication Date (Web): 05 Feb 2019
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Pd(II)-Catalyzed Direct Sulfonylation of Benzylamines using
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Ujjwal Karmakar and Rajarshi Samanta*
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Supporting Information
ABSTRACT: A Pd(II)-catalyzed direct sulfonylation of benzylamines with sodium sulfinates using removable bidentate directing group
is illustrated. The transformation is highly regioselective and tolerates wide functional groups. The mechanistic study reveals that radical
species are involved in this reaction. This method delivers a direct synthetic strategy to obtain highly functionalized sulfonylated
benzylamines.
INTRODUCTION
Sulfones represent a ubiquitous structural motif having rich pharmaceutical and advanced materials applications.1 Further, this scaffold is
also a well-admired precursor for important synthetic transformations like Julia olefination or Ramberg-Bäcklund reaction.2 Though
there is a significant advancement in the synthesis of sulfones in different ways3, straightforward introduction of sulfone group in direct
C-H bonds attracts more attention due to its simplicity, step-economic nature and avoiding of drastic reaction conditions.4 Since the
pioneering work by Dong group on Pd(II)-catalyzed sulfonylation5, site-selective sulfonylation of C-H bonds has been explored on
different type of substrates using transition metals like Pd,5,6 Rh,7 Ru,8 Cu9and Ni.10 Importantly, a significant progress has been achieved
in the transition metal catalyzed sulfonylation of benzamide derivatives with the aid of bidentate directing group. However, due to the
omnipresence of ortho-sulfonylated benzylamine scaffolds in biologically important compounds (Figure 1), a direct, catalytic, site-
selective method for the preparation of these moieties is highly required. In general, the flexible geometry of the substrate and its poor
stability under the oxidizing conditions make the task more challenging.
Figure 1: Biologically relevant sulfonylated benzylamine scaffolds
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Recently, Shi and co-workers developed a copper(II)-catalyzed direct sulfonylation of benzamide derivatives using sodium
sulfinate as coupling partner (Scheme 1i).9d Manolikakes and co-workers also developed a copper-mediated sulfonylation with
sodium sulfinate using an amide tethered oxazoline directing group.9e Chatani’s and Kambe’s group independently exhibited
Ni(II)-catalyzed sulfonylation of benzamide derivative using 8-aminoquinoline based bidentate directing group.10a-b Recently,
Gong and Song’s group revealed Ni(II)-catalyzed version of this transformation (Scheme 1ii).10c Very recently, Xia and Wu's
group explored a Pd(II)-catalyzed sulfonylation of benzamide derivative having 8-aminoquinoline based bidentate directing
group.6f Notably, previous reports of sulfonylation are limited with structurally rigid, electron–deficient benzamide moieties.
Nevertheless, sodium sulfinates were selected as the strategic sulfonylating reagent due to its easy accessibility and firm
stability.3d, 3i Since the pioneering development of arylation of benzylamine substrates11, other important transformations like
alkenylation12, alkynylation13, alkylation14, trifluoromethylation15, and carbonylation16 were illustrated in the literature. Despite
the elegance of the approaches mentioned above, as per our best of knowledge, a direct, catalytic, site-selective sulfonylation of
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benzylamines remains a strategic challenge.
Scheme 1. Pd(II)-Catalyzed Direct C(sp2)-H Sulfonylation of Benzylamine
sp2 C-H sulfonylation of bezamides using bidentate directing group
Previous work
O
O
i) Shi, Cu(II) cat.
ii) Manolikakes, Cu(II)
mediated
[TM]
DG
DG
ArSO2 source
iii) Gong & Song, Ni(II) cat.
iv) Chatani and Kambe,
Ni(II) cat.
SO2Ar
v) Xia & Wu, Pd(II) cat.
sp2 C-H sulf onylation of bezylamines with ArSO2Na
Present work
R
R
O
NHDG
SO2Ar
NHDG
[Pd]
DG =
ArSO2Na
H
N
R = H, Me
Intrigued by our recent studies on transition metal catalyzed C-H functionalizations17 and related Pd(II)-catalyzed
sulfonylation studies5,6, we hypothesized that Pd(II)-catalyst might help in our desired sulfonylation on benzylamine scaffold.
Bidentate directing-group in C-H activation is well appreciated due to its ability towards stabilizing the higher oxidation state of
transition metals and delivering the active catalytic site to a nearest C-H bond. Herein, we report a Pd(II)-catalyzed ortho-
sulfonylation of benzylamines guided by removable bidentate picolinamide group18 with the sodium sulfinates as sulfonylating
agent.
RESULTS AND DISCUSSION
Table 1. Optimization of Reaction Conditionsa
entry solvent
oxidant
-
additive (mol %)
yieldb
n.d.
31
1
2
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7
8
DCE
-
-
-
-
-
-
-
-
DCE
Ag2CO3
Ag2CO3
Ag2CO3
Ag2CO3
Ag2CO3
toluene
butanol
HFIP
TFE
n.d.
n.d.
28
38
DCE/TFE (1:1) Ag2CO3
DCE/TFE(1:1) AgOAc
42
36
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DCE/TFE(1:1)
DCE/TFE(1:1)
DCE/TFE(1:1)
DCE/TFE(1:1)
DCE/TFE(1:1)
DCE/TFE(1:1)
DCE/TFE(1:1)
DCE/TFE(1:1)
AgNO3
Ag2O
-
-
n.d.
n.d.
53
58
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69
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54
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Ag2CO3 LiOAc.2H2O(100)
Ag2CO3 NaOAc (100)
Ag2CO3 KOAc (100)
Ag2CO3 BzOH (50)
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Ag2CO3 4-MeBzOH (50)
Ag2CO3 2,6-OMeBzOH (50)
DCE/TFE(1:1) Ag2CO3 mesitoic acid (50)
DCE/TFE(1:1)
DCE/TFE(1:1)
Ag2CO3 1-AdCO2H (50)
Ag2CO3 mesitoic acid (20)
aReaction conditions: 1a (0.1 mmol), 2a (0.2 mmol), Pd(OAc)2 (10 mol %), oxidant (0.2 mmol), additive, solvent (0.1 M), 110 °C, 24 h. bIsolated
yields. n.d. = not detected. TFE = 2,2,2-trifluoroethanol.
Our investigation commenced with a possible Pd(II)-catalyzed sulfonylation of picolinamide protected benzylamine (1a) with
sodium sulfinate (2a) as a coupling partner (Table 1). Initially, in the absence of any silver salt, there was no desired product
formation (Table1, entry 1). Gratifyingly, the acceptable yield of desired product 3a was isolated when the reaction was
performed with Ag2CO3 oxidant in DCE solvent (Table 1, entry 2). Screening of other solvents provided an improved yield of
3a in 1:1 solvent mixture of DCE and 2,2,2-trifluoroethanol with 42% of 3a (Table 1, entries 3-7). Examination of other silver
salts (Table 1, entries 8-10) and different oxidants were tested (see supporting information) with no better results. Considering
the significant role of the acetates in direct C-H bond functionalizations19, relevant acetates were screened. Pleasingly, the yield
of the desired product was improved (Table 1, entries 11-13). Furthermore, a thorough investigation of versatile carboxylic
acids in 50 mol% (see supporting information) as additives revealed that the reaction proceeded efficiently with mesitoic acid
to afford the desired product 3a in 69% isolated yield (Table 1, entries 14-18). However, lowering the loading of additive
decreased the yield of the desired product (Table 1, entry 19). Finally, the structure of 3a was unequivocally determined
through single crystal x-ray analysis.
Scheme 2. Scope of Benzylamine Derivatives:
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9
Pd(OAc)2 (10 mol %)
Ag2CO3 (2 equiv)
PhSO2Na (2 equiv)
O
DG
DG
DG
N
H
N
H
R
R
mesitoic acid (50 mol %)
DCE:TFE (1:1), 110 °C
N
SO2Ph
1
DG
OCH3
3
DG
DG
N
H
N
H
N
H
DG
N
SO2Ph
H
H3C
SO Ph
H3CO
2
SO2Ph
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SO2Ph
3d, 65%, 24 h
3b, 64%, 24 h
3a [x-ray], 69%,
24 h
3c, 66%, 24 h
CH3
DG
H3CO
DG
DG
N
H
N
H
R1 = F, 3g, 51%, 24 h
= Cl, 3h, 58%, 24 h
= Br, 3i, 56%, 24 h
N
R1
SO2Ph
H
SO2Ph
SO2Ph
3e, 69%, 24 h
Cl
3f, 79%, 24 h
DG
Cl
DG
DG Br
DG
N
H
N
H
N
H
N
H
F3C
SO2Ph
SO2Ph
SO2Ph
SO2Ph
3k, 61%, 24 h
3l, 66%, 24 h
3m, 42%, 34 h
3j, 57%, 24 h
DG
H3CO
DG
MeO2C
DG
N
N
H
N
H
H
H3C
O
SO2Ph
H3CO
SO2Ph
SO2Ph
3p, 89%, 18 h
3o, 58%, 24 h
3n, 52%, 24 h
CH3
DG
OCH3
O
DG
N
DG
N
H
H
H3CO
DG
(R)
N
N
H
H
SO2Ph
SO2Ph
SO2Ph
SO2Ph
3r, 72%, 24 h
3t, 79%, 24 h
3s, 60%, 24 h
3q, 83%, 20 h
DG
DG
S
N
N
H
H
N
SO2Ph
SO2Ph
3u, 86 %, 24 h
3v, 78%, 24 h
Reaction conditions: 1 (0.1 mmol), 2a (0.2 mmol), Pd(OAc)2 (10 mol %), Ag2CO3 (0.2 mmol), mesitoic acid (50 mol %), DCE:TFE (1:1; 0.1 M),
110 °C
With the optimized reaction protocol, we investigated the broadness in the scope of the reaction (Scheme 2). Synthetically
acceptable yields of the sulfonylated products were obtained for substrates containing electron donating groups at its ortho,
meta or para position (Scheme 2, 3a-3f). Interestingly, meta-methoxy substrate afforded single sulfonylated regioisomer 3f in
79% yield. Halogen substitutions at the ortho, meta, and para-position of benzylamines were also well tolerated with moderate
to good yields (Scheme 2, 3g-3l). Notably, halogens were survived under Pd(II)-catalyzed conditions without proceeding
through the expected oxidative addition. Furthermore, the relatively lower yield of the desired product was achieved when
electron-withdrawing CF3, keto or ester groups were tethered at benzylamines (Scheme 2, 3m-3o). Next, highly electron-rich
substrates with dimethoxy group worked better with excellent yields (Scheme 2, 3p-3q). Interestingly, naphthalen-2-
ylmethanamine derivative (1r) provided sulfonylation at the sterically less crowded position in very good yield (Scheme 2, 3r).
It is noteworthy that the optical purity of the benzylamine derivative (1s) was firmly tolerated under the developed conditions
to provide enantiopure compound 3s (see supporting information). Significantly, heterocyclic scaffolds like furan and
thiophene derivatives provided expected sulfonylated products (Scheme 2, 3t-3u). Appreciating yield and regioselectivity was
observed with indole derivative during desired sulfonylation (Scheme 2, 3v).
Scheme 3. Scope Using Various Sulfinates:
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Reaction conditions: 1a (0.1 mmol), 2 (0.2 mmol), Pd(OAc)2 (10 mol %), Ag2CO3 (0.2 mmol), DCE:TFE (1:1; 0.1 M), 110 °C, 24 h. a30 h.
The reaction was explored with various sodium sulfinates having different electronic and steric properties (Scheme 3, 4a-4h).
Various functional groups like alkyl, methoxy, halogens were well accommodated during transformation. It is important to
mention that the survival of halides during transformation provided the synthetic post modification opportunity (Scheme 3, 4f-
4g). Next, a bulky naphthylsulfinate also afforded desired product in very good yield (Scheme 3, 4h). Unfortunately, there was
no desired products formation when the reactions were carried out with meta-CF3 benzene sulfinate salt or alkyl sulfinate salt,
CH3SO2Na under optimized conditions.
Scheme 4. Product modifications and applications:
The diverse applicability of the developed method was explored through the post-operation modifications of 3a (Scheme 4).
Treatment of 3a with iodobenzene under Pd(OAc)2 catalyzed conditions offered ortho-phenylated product 5.20 Next, 3a was
undergone through Pd(OAc)2 catalyzed ortho-acetoxylation using PhI(OAc)2 to provide compound 6 in 66% yield.21 Further,
ortho-alkylation was carried out with the diazo compound under Rh(III)-catalyzed conditions to provide compound 7.
Furthermore, Rh(III)-catalyzed regio-selective, oxidative olefination at pyridine core of 3a and subsequent cyclization afforded
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compound 8.22 Deprotection of 3a furnished compound 9 which could be transformed to a pharmaceutically active compound
10 via literature known method.23
6
7
Scheme 5. Control experiments:
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To delineate the probable mechanistic pathway of the reaction, required control experiments were conducted (Scheme 5). To
reveal the radical intermediate’s involvement, the reaction was carried in the presence of radical quenchers like 2,2,6,6-
tetramethylpiperidin-1-yl-)oxidanyl (TEMPO) and 2,6-di-tert-butyl-4-methylphenol (BHT). Incidentally,
a significant
amount of inhibition in the formation of the desired product was noticed (Scheme 5i) with the isolation of radical trapped
adduct 11. Next, the reaction rate (Scheme 5ii) for electron-rich benzylamine (1c) was found faster over electron-deficient
benzylamine (1m). The H/D scrambling experiment on 1b in the absence of sodium sulfinate (2a) revealed that the C-H
metalation was largely reversible. However, no deuterium incorporation was found when the reaction was carried out in the
presence of sodium sulfinate (2a). This result indicated that steps following the C-H metalation were not reversible (Scheme
1
5iii). A KIE value ~1.2 was determined via H NMR analysis of the recovered picolinamide mixture from the intermolecular
competitive experiment. Further, in a competitive parallel experiment, the KIE value of ~1.3 was measured via the starting
material recovery (see supporting information). These findings proposed that the C−H bond activation at the benzylamine
derivative was not the rate-determining step (Scheme 5iv). Reactions of N-alkyl protected benzylamines (1x or 1y) with
PhSO2Na (2a) did not furnish the corresponding target products 12 or 13 (Scheme 5v). This result exhibited the crucial
bichelate-directing role of pyridyl and amide “N” in enabling the site-selective sulfonylation reaction. Based on the above
observations and related literature,5,6, 11-16 a probable mechanism based on Pd(II)/Pd(IV) catalytic cycle is proposed (Scheme
6).
Scheme 6: Plausible mechanism for sulfonylation:
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Initially, N,N’-bidentate directing group of 1a coordinates with Pd(II)-catalyst to form A. Next; carboxylic acid assisted C-H
bond metalation provides 5-membered palladacycle B which could be in equilibrium with its dimer. Subsequently, silver salt
mediated single-electron oxidation of sodium sulfinate affords the corresponding sulfonyl radical which further leads to the
formation of Pd(IV)-complex C.4c,9d,10a Finally, the reductive elimination of C and subsequent protonation provides the
sulfonylated product 3a with the regeneration of active Pd(II)-catalyst. However, the possibility of bimetallic Pd(II)/Pd(III)
catalytic cycle cannot be totally ruled out at this stage. 24
CONCLUSION
In summary, we have developed a direct Pd(II)-catalyzed site-selective sulfonylation of benzylamines using sodium sulfinates
as coupling partner and guided by the removable bidentate picolinamide group. The method was explored with diverse
functional group tolerance. The involvement of radical species in the catalytic cycle was revealed. The H/D scrambling study
showed that C-H bond cleavage was reversible. Moreover, the sulfonylated benzylamines were further explored with sequential
functional groups incorporation.
EXPERIMENTAL SECTION
General:
All commercially available compounds were used without further purification. Solvents for elution in the column were distilled.
Analytical thin layer chromatography (TLC) was performed on pre- coated silica gel 60 F254. Visualization on TLC was
1
achieved by the use of UV light (254 nm). Column chromatography was undertaken on silica gel (230-400 mesh). H NMR
spectra were recorded on BRUKER ULTRA SHIELD machine (400 MHz, 500 MHz, and 600 MHz). 13C NMR spectra were
recorded on BRUKER machine (150, 125 and 100 MHz) and were fully decoupled by broadband proton decoupling.
Chemical shifts were quoted in parts per million (ppm) referenced to the appropriate solvent peak or 0.0 ppm for
tetramethylsilane. The following abbreviations were used to describe peak splitting patterns when appropriate: s= singlet, d=
doublet, t= triplet, q= quartet, dd= doublet of doublet, dt= doublet of triplet, m= multiplet. Coupling constants, J, were
reported in hertz unit (Hz). Chemical shifts were reported in ppm referenced to the center of a triplet at 77.16 ppm of CDCl3.
19F NMR spectra were recorded on BRUKER machine (376 MHz). Fourier Transform Infrared Spectroscopy (FT-IR) was
obtained with a Bruker Alpha ATR spectrometer and selected absorbance peaks are reported in terms of frequency of
absorption (cm-1). High-resolution mass spectra were obtained from waters XEVO-G2QTOF by using TOF MS ESI+ method.
Materials were obtained from commercial suppliers or prepared according to standard procedures unless otherwise noted.
HPLC analysis was performed on SHIMADZU LC 20 AD having PDA detector and chiralcel OD-H column under mobile
phase (hexane: isopropanol = 9:1) 1mL/min flow rate.
General procedure for the synthesis of substituted Benzylamine compounds:25
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Substituted aromatic aldehydes (1 mmol) were taken in a 50 mL round bottom flask and hydroxylamine hydrochloride (1.2
mmol) was added to it. Ethanol and water (1:4) mixture were (6 mL) added to the reaction mixture. Sodium carbonate (1.2
mmol) was added and the reaction mixture stirred for 6 h at room temperature. The solvent was removed by using rotary
evaporator. The product was partitioned between ethyl acetate and water. The organic layer was dried over anhydrous Na2SO4,
concentrated under reduced pressure and directly taken for next step without further modification. Most of the benzylamines
were procured from commercially available sources. The remaining benzylamines were prepared by following procedures and
the analytical data matched with reported values.
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Procedure A: Corresponding oxime product (1 mmol) was taken in 10 mL acetic acid. Subsequently, zinc dust (6 equiv) was
added to the reaction flask and heated 100 °C for 12 to 24 h and monitored by TLC. Upon completion, sodium bicarbonate was
added to the reaction mixture. The mixture was extracted with ethyl acetate (3 × 15 mL). The combined organic phase was
washed with brine and dried over anhydrous Na2SO4. The product was purified by column chromatography to get pure
benzylamine compounds. The analytical data prepared compounds matched with reported value.
°
Procedure B: Corresponding oxime product (1 mmol) was taken in 10 mL dry THF and cooled to 0 C. Lithium aluminum
hydride (1.5 mmol) was added to it very slowly, and the reaction mixture was stirred for 12 h at room temperature. Upon
completion, a saturated ammonium chloride solution was added to the reaction mixture. The mixture was extracted with ethyl
acetate (3 × 15 mL). The combined organic phase was washed with brine and dried over anhydrous Na2SO4. The product was
purified by column chromatography to get pure benzylamine compounds.
General procedure for the synthesis of substituted N-Benzylpicolinamide compounds:26, 13d, 14a
Procedure A: Substituted benzylamine derivatives (1 mmol), picolinic acid (1.2 mmol), EDC.HCl (1.2 mmol), HOBT (1.2
mmol), N,N-diisopropylethylamine (DIPEA) (2.5 mmol) were taken in a 50 mL round bottom flask containing 10 mL
anhydrous DMF. The reaction mixture was stirred for 24 h at room temperature. Upon completion, the reaction mixture was
partitioned between ethyl acetate and water. The combined organic phase was washed with brine and dried over anhydrous
Na2SO4. The crude product was purified by column chromatography to get pure product (1a-1n, 1p-1s, 1v). The analytical
data of the compounds found similar with reported value. 26, 13d, 14a The analytical data of new compound 1v was given.
Procedure B: A 50 mL round-bottomed flask was charged with picolinic acid (1 mmol) and dry dichloromethane (10 mL)
°
was added to it. It was cooled to 0 C in an ice water bath. To the stirred suspension oxalyl chloride (1.1 mmol), was added
dropwise followed by addition of DMF (catalytic amount) in one portion. The mixture was kept in the cooling bath for 1 h and
then allowed to warm to room temperature. The mixture was cooled to 0 °C and NEt3 (2 mmol) was added dropwise followed
by substituted benzylamine (1.1 mmol). The mixture was left in the cooling bath for 30 minutes and then allowed to warm to
room temperature. Stirring was continued at room temperature for 2 h. Removal of solvent in vacuo gave the crude product
that was partitioned between DCM and water. The organic phases were combined dried over Na2SO4 and concentrated under
reduced pressure and purified by column chromatography to give corresponding N-Benzylpicolinamide compounds. (1t-1u).
The Analytical data of 1t was matched with reported value.13d Analytical data of newly synthesized compound 1u was reported
here.
Procedure for the synthesis of Methyl 3-(picolinamidomethyl)benzoate (1o)
°
3-cyanobenzoic acid (1g, 6.8 mmol) was dissolved in dry methanol (20 mL). The solution was cooled to 0 C. Then thionyl
chloride (0.5 mL, 1.5 equiv) was added to the reaction mixture drop-wise and stirred for 10 h at room temperature. After
completion of the reaction the solvent was evaporated and the crude reaction mixture was partitioned between ethyl acetate
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and water. The organic layer was dried over Na2SO4, concentrated under reduced pressure and directly taken for next step
without further purification. (910 mg, yield: 83 %)
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Corresponding 3-cyanobenzoic acid ester compound (400 mg, 2.48 mmol) was taken in dry methanol (10 mL) and cooled to
0 °C. To this reaction mixture concentrated HCl (0.3 mL) followed by Pd/C (10 wt %) was added and kept it under hydrogen
atmosphere by using a H2 balloon and stirred for 24 h at room temperature. After completion of the reaction, the reaction
mixture was filtered through celite and was washed with methanol. The solvent was concentrated under reduced pressure and
directly taken for next step without further purification.
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°
The corresponding benzylamine product (1 mmol) was dissolved in dry dichloromethane and cooled to 0 C. To this reaction
mixture 2-picolinic acid (1.2 mmol), followed by EDC.HCl (2.1mmol) and DMAP (2 mmol) were added. The reaction
mixture was stirred for 6 h at room temperature. After completion of the reaction, the reaction mixture was partitioned between
DCM and water. The organic layer was dried over Na2SO4 and concentrated under reduced pressure and purified by column
chromatography to give methyl 3-(picolinamidomethyl)benzoate (1o) as a white solid product in 56% yield (151.3 mg).
General procedure for the synthesis of substituted aryl sulfinates salts: 9c, 27
Substituted aromatic sulfonyl chloride (1 mmol) was taken in a 50 mL round bottom flask. Subsequently, Na2SO3 (2 mmol),
sodium bicarbonate (2 mmol) and distilled water (10 mL) were added to the flask. Next, the reaction mixture was stirred for 8
°
h at 80 C. Water was removed under reduced pressure. The solid white product was recrystallized by ethanol and dried in
vaccuo. The products were compared with known literature data9c, 27 and used directly without further modification.
General procedure for Pd(OAc)2-catalyzed N-(2(Phenylsulfonyl)benzyl)picolinamide synthesis:
N-Benzylpicolinamide derivative 1 (0.1 mmol) was dissolved in 0.5 mL 2,2,2-trifluroethanol and 0.5 mL DCE ( 1:1) in a 10
mL screw cap vial. Then Pd(OAc)2 (10 mol %, 2.24 mg), Ag2CO3(2 equiv, 54 mg), mesitoic acid (50 mol %, 8.2 mg) and
sodium sulfinate (2 equiv, 33 mg) 2a were added to the reaction mixtures at room temperature and the reaction mixture was
°
stirred for 18-34 h at 110 C. After completion of the reaction, the solvent was evaporated, and the crude product was
partitioned between ethyl acetate and water. Saturated sodium bicarbonate solution was added. The organic layer was dried
over Na2SO4 and concentrated under reduced pressure and directly loaded to the column to obtain a pure product with
hexane/ethyl acetate as eluent (40-60 % EA/PE).
Large scale experiment:
In a 50 mL round bottom flask 1a (424.5 mg, 2 mmol) was dissolved in 5 mL 2,2,2- trifluroethanol and 5 mL DCE (1:1). Then
Pd(OAc)2 (10 mol %, 45 mg), Ag2CO3 (2 equiv, 1.1 g), mesitoic acid (50 mol %, 164.2 mg) and sodium sulfinate (2 equiv,
°
656.6 mg) 2a were added to the reaction mixture at room temperature and the reaction mixture was stirred for 24 h at 110 C.
After completion of the reaction, the solvent was evaporated and the crude product was partitioned between ethyl acetate and
water. Saturated sodium bicarbonate solution was added. The organic layer dried over Na2SO4 and concentrated under
reduced pressure and directly loaded to the column to obtain pure product 3a with hexane/ethyl acetate as eluent with 55 %
yield (387.4 mg).
SYNTHETIC APPLICATION
Procedure for aryalation of 3a:
Compound 3a (0.1 mmol, 35.2 mg) was dissolved in 1 mL of tert amyl alcohol in a 10 mL screw cap vial. Then Pd(OAc)2 (10
mol %, 2.24 mg), CuBr2 (20 mol %, 4.5 mg ), CsOAc (4 equiv, 76 mg) and iodobenzene (3 equiv, 61 mg) were added to the
°
reaction mixture. The reaction mixture was allowed to stir at 120 C for 20 h. After completion of the reaction, the reaction
mixture was concentrated and directly purified by flash column chromatography to obtain product 5.
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Procedure for acetoxylation of 3a:
Compound 3a (0.1 mmol, 35.2 mg) was dissolved in 1 mL of toluene in a 10 mL screw cap vial. Then Pd(OAc)2 (10 mol %,
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2.24 mg), diacetoxyiodobenzene (2 equiv, 66 mg) were added to the reaction mixture. The reaction mixture was allowed to stir
°
at 120 C for 24 h. After completion of the reaction, the reaction mixture was concentrated and directly purified by flash
9
column chromatography to obtain product 6.
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Procedure for Rh(III)-catalysed alkylation of 3a with diazoketo ester:
Compound 3a (0.1 mmol, 35.2 mg) was dissolved in 1mL 2,2,2- trifluoroethanol in a 10 mL screw cap vial. Then
[(Cp*RhCl2)2] (2.5 mol%, 1.5 mg), AgSbF6 (10 mol%, 3.5 mg) and diazoketoester (2 equiv, 32 mg) were added to the reaction
°
mixture at room temperature. Then the reaction mixture was stirred at 90 C for 12 h. After completion of the reaction, it was
concentrated and directly loaded to the column to obtain pure product 7.
Procedure for Rh(III)-catalyzed alkenylation of 3a:
Compound 3a (0.1 mmol, 35.2 mg) was dissolved in 1 mL of 1,4-dioxane in a 10 mL screw cap vial. Then [(Cp*RhCl2)2] (2.5
mol%, 1.5 mg), AgSbF6 (10 mol%, 3.5 mg) and methyl acrylate (2 equiv, 0.018 mL) were added to the reaction mixture at
°
room temperature. The reaction mixture was warmed to 120 C and stirred for 16 h. After completion of the reaction, it was
concentrated and directly loaded to the column to get the product 8 after purification.
Removal of picolinamide directing group:
Compound 3a (0.1 mmol, 35.2 mg) and KOH (60.0 equiv, 336 mg) were taken in a 20 mL reaction vessel. Then it was sealed
°
with a Teflon lined cap and ethanol (4 mL) was added via syringe. The resulting mixture was stirred at 120 C for 24 h. After
completion of the reaction, the reaction mixture was cooled down to room temperature, diluted by 30 mL of ethyl acetate and
washed with water (2 × 20 mL). The organic layer was dried over Na2SO4 and concentrated in vacuo and the crude product was
purified by column chromatography to give corresponding amine product 9 in 80% yield (19.8 mg) as a yellow oil. The
analytical data of the compound was compared with known literature data.23
Analytical data of new N-Benzylpicolinamide compounds:
N-(4-Acetylbenzyl)picolinamide (1n); white solid, (66%, 167.8 mg); 1H NMR (600 MHz, CDCl3) δ 8.54 (d, J = 4.1 Hz, 1H),
8.48 (s, 1H), 8.23 (d, J = 7.8 Hz, 1H), 7.93 (dd, J = 8.2, 1.7 Hz, 2H), 7.85 (m, 1H), 7.44 (t, J = 6.9 Hz, 3H), 4.73 (d, J = 6.4 Hz,
2H), 2.58 (s, 3H); 13C{1H} NMR (150 MHz, CDCl3) δ 197.7, 164.5, 149.8, 148.2, 143.9, 137.6, 136.6, 128.9, 127.9, 126.5,
~
122.6, 43.3, 26.7; FT-IR: = 3052, 2924, 1670, 1608, 1570, 1521, 1465, 1415, 1359, 1268, 1162, 1117, 1089 cm-1; HRMS:
calculated for [M+H]+ C15H15N2O2: 255.1128, found 255.1125.
1
Methyl 3-(picolinamidomethyl)benzoate (1o); white solid, (56%, 151.3 mg); H NMR (400 MHz, CDCl3) δ 8.53 (d, J = 4.4
Hz, 1H), 8.45 (s, 1H), 8.23 (d, J = 7.8 Hz, 1H), 8.03 (s, 1H), 7.95 (dd, J = 7.8, 1.5 Hz, 1H), 7.86 (td, J = 7.7, 1.7 Hz, 1H), 7.58
(d, J = 7.5 Hz, 1H), 7.42 (q, J = 7.6 Hz, 2H), 4.72 (d, J = 6.2 Hz, 2H), 3.90 (s, 3H); 13C{1H} NMR (150 MHz, CDCl3) δ 167.0,
~
164.5, 149.8, 148.2, 138.8, 137.6, 132.6, 130.7, 129.0, 128.9, 128.8, 126.5, 122.6, 52.3, 43.3; FT-IR: = 3058, 2924, 2854,
1719, 1668, 1591, 1522, 1465, 1435, 1357, 1287, 1207, 1108, 1088 cm-1; HRMS: calculated for [M+H]+ C15H15N2O3:
271.1077, found 271.1093.
1
N-(2,3-Dimethoxybenzyl)picolinamide (1q); gray solid, (76%, 206.9 mg); H NMR (600 MHz, CDCl3) δ 8.52 (d, J = 3.9 Hz,
1H), 8.42 (s, 1H), 8.21 (d, J = 7.8 Hz, 1H), 7.83 (td, J = 7.6, 1.7 Hz, 1H), 7.38 (m, 1H), 7.02 (t, J = 7.8 Hz, 1H), 6.98 (dd, J =
7.8, 1.7 Hz, 1H), 6.87 (dd, J = 8.0, 1.7 Hz, 1H), 4.69 (d, J = 6.1 Hz, 2H), 3.92 (s, 3H), 3.87 (s, 3H); 13C{1H} NMR (150 MHz,
~
CDCl3) δ 164.3, 152.9, 150.3, 148.2, 147.6, 137.4, 132.1, 126.2, 124.3, 122.4, 121.6, 112.2, 61.0, 56.0, 38.9; FT-IR: = 3056,
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2924, 2850, 1674, 1590, 1524, 1482, 1434, 1356, 1275, 1223, 1170, 1081 cm-1; HRMS: calculated for [M+H]+ C15H17N2O3:
273.1234, found 273.1256.
1
N-(Thiophen-2-ylmethyl)picolinamide (1u); brown solid, (63%, 137.5 mg); H NMR (400 MHz, CDCl3) δ 8.53 (d, J = 4.6
Hz, 1H), 8.41 (s, 1H), 8.23 (d, J = 7.8 Hz, 1H), 7.86 (td, J = 7.7, 1.7 Hz, 1H), 7.43 (m, 1H), 7.23 (dd, J = 5.1, 1.3 Hz, 1H), 7.05
(m, 1H), 6.97 (dd, J = 5.1, 3.4 Hz, 1H), 4.84 (d, J = 6.0 Hz, 2H); 13C{1H} NMR (100 MHz, CDCl3) δ 164.1, 149.8, 148.2,
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~
140.9, 137.6, 127.0, 126.4, 126.3, 125.3, 122.6, 38.4; FT-IR: = 3058, 2924, 1668, 1570, 1519, 1465, 1436, 1368, 1290, 1168,
1088 cm-1; HRMS: calculated for [M+Na]+ C11H10N2NaOS: 241.0406 found 241.0413.
1
N-((1-Methyl-1H-indol-5-yl)methyl)picolinamide (1v); reddish solid, (68%, 180.4 mg); H NMR (600 MHz, CDCl3) δ 8.49
(d, J = 4.2 Hz, 1H), 8.35 (s, 1H), 8.25 (d, J = 7.8 Hz, 1H), 7.86 (m, 1H), 7.63 (s, 1H), 7.40 (m, 1H), 7.30 (d, J = 8.4 Hz, 1H),
7.25 (dd, J = 8.5, 1.6 Hz, 1H), 7.06 (d, J = 3.0 Hz, 1H), 6.46 (d, J = 3.0 Hz, 1H), 4.76 (d, J = 5.9 Hz, 2H), 3.79 (s, 3H); 13C{1H}
NMR (150 MHz, CDCl3) δ 164.1, 150.2, 148.1, 137.4, 136.3, 129.5, 129.1, 128.8, 126.2, 122.4, 122.2, 120.6, 109.6, 101.0, 44.3,
~
33.0; FT-IR: = 3055, 2924, 2855, 1667, 1569, 1515, 1464, 1434, 1338, 1305, 1245, 1156, 1086 cm-1; HRMS: calculated for
[M+H]+ C16H16N3O: 266.1288, found 266.1286.
Analytical data of N-(2(Phenylsulfonyl)benzyl)picolinamide:
°
N-(2-(Phenylsulfonyl)benzyl)picolinamide (3a); Crystalline solid, m.p. 134 - 136 C, (69%, 24.3 mg); Rf = 0.42 (40%
1
EA/PE); H NMR (400 MHz, CDCl3) δ 8.72 (s, 1H), 8.55 (d, J = 3.2 Hz, 1H), 8.15 (t, J = 6.9 Hz, 2H), 7.92 (d, J = 7.7 Hz,
2H), 7.81 (t, J = 7.7 Hz, 1H), 7.66 (d, J = 7.7 Hz, 1H), 7.62 – 7.54 (m, 2H), 7.51 – 7.45 (m, 3H), 7.39 (m, 1H), 4.84 (d, J = 6.7
Hz, 2H); 13C{1H} NMR (100 MHz, CDCl3) δ 164.5, 149.8, 148.4, 141.6, 139.0, 137.9, 137.3, 134.4, 133.5, 132.3, 130.0, 129.5,
~
128.4, 127.5, 126.3, 122.4, 40.6; FT-IR: = 3053, 2924, 2853, 1682, 1591, 1514, 1463, 1434, 1356, 1254, 1238, 1151, 1086
cm-1; HRMS: calculated for [M+H]+ C19H17N2O3S: 353.0954, found 353.0971.
N-(4-Methyl-2-(phenylsulfonyl)benzyl)picolinamide (3b); amorphous solid, (64%, 23.5 mg); Rf = 0.38 (40% EA/PE); 1H
NMR (400 MHz, CDCl3) δ 8.68 (t, J = 6.7 Hz, 1H), 8.54 (d, J = 4.6 Hz, 1H), 8.14 (d, J = 7.6 Hz, 1H), 7.99 (s, 1H), 7.92 (d, J =
7.6 Hz, 2H), 7.81 (td, J = 7.7, 1.7 Hz, 1H), 7.62 – 7.45 (m, 4H), 7.42 – 7.34 (m, 2H), 4.77 (d, J = 6.6 Hz, 2H), 2.42 (s, 3H);
13C{1H} NMR (125 MHz, CDCl3) δ 164.4, 149.9, 148.4, 141.9, 138.8, 138.6, 137.3, 135.1, 135.0, 133.4, 132.5, 130.4, 129.5,
~
127.4, 126.3, 122.4, 40.3, 21.2; FT-IR: = 3061, 2924, 2854, 1674, 1570, 1516, 1463, 1435, 1353, 1303, 1243, 1161, 1084 cm-
1; HRMS: calculated for [M+H]+ C20H19N2O3S: 367.1111, found 367.1123.
1
N-(4-Methoxy-2-(phenylsulfonyl)benzyl)picolinamide (3c); amorphous solid, (66%, 25.2 mg); Rf = 0.30 (40% EA/PE); H
NMR (400 MHz, CDCl3) δ 8.67 (t, J = 5.7 Hz, 1H), 8.54 (d, J = 4.6 Hz, 1H), 8.14 (d, J = 7.8 Hz, 1H), 7.92 (d, J = 7.3 Hz, 2H),
7.81 (td, J = 7.8, 1.7 Hz, 1H), 7.69 (d, J = 2.7 Hz, 1H), 7.60 – 7.57 (m, 2H), 7.51 (dd, J = 8.3, 6.7 Hz, 1H), 7.40 (m, 1H), 7.07
(dd, J = 8.4, 2.8 Hz, 1H), 4.73 (d, J = 6.5 Hz, 2H), 3.86 (s, 3H); 13C{1H} NMR (125 MHz, CDCl3) δ 164.4, 159.3, 149.9, 148.4,
~
141.6, 139.9, 137.3, 134.1, 133.5, 129.7, 129.5, 127.4, 126.3, 122.4, 119.9, 115.1, 55.9, 40.0; FT-IR: = 3062, 2926, 2855,
1665, 1606, 1570, 1522, 1446, 1360, 1290, 1241, 1156, 1043 cm-1; HRMS: calculated for [M+H]+ C20H19N2O4S: 383.1060,
found 383.1061.
1
N-(2-Methoxy-6-(phenylsulfonyl)benzyl)picolinamide (3d); amorphous solid, (65%, 24.8 mg); Rf = 0.32 (40% EA/PE); H
NMR (600 MHz, CDCl3) δ 8.49 (d, J = 4.6 Hz, 1H), 8.21 (s, 1H), 8.17 (d, J = 7.8 Hz, 1H), 7.91 (dd, J = 8.1, 1.5 Hz, 2H), 7.86
(d, J = 8.0 Hz, 1H), 7.81 (td, J = 7.7, 1.6 Hz, 1H), 7.53 – 7.42 (m, 4H), 7.37 (m, 1H), 7.17 (d, J = 8.3 Hz, 1H), 4.89 (d, J = 5.7
Hz, 2H), 3.86 (s, 3H); 13C{1H} NMR (100 MHz, CDCl3) δ 163.7, 159.5, 150.2, 148.2, 141.8, 141.5, 137.2, 133.3, 129.4, 129.4,
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127.6, 126.0, 125.4, 122.4, 121.6, 116.5, 56.6, 34.1; FT-IR: = 3061, 2922, 2853, 1668, 1608, 1576, 1518, 1445, 1366, 1291,
1239, 1152, 1046 cm-1 ; HRMS: calculated for [M+H]+ C20H19N2O4S: 383.1060, found 383.1071.
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N-(2-Methyl-6-(phenylsulfonyl)benzyl)picolinamide (3e); amorphous solid, (69%, 25.3 mg); Rf = 0.40 (40% EA/PE) 1H
NMR (400 MHz, CDCl3) δ 8.52 (d, J = 4.8 Hz, 1H), 8.48 (s, 1H), 8.16 (d, J = 7.7 Hz, 1H), 8.09 (d, J = 7.7 Hz, 1H), 7.93 – 7.83
(m, 2H), 7.82 (td, J = 7.7, 1.7 Hz, 1H), 7.57 – 7.45 (m, 4H), 7.44 – 7.36 (m, 2H), 4.81 (d, J = 6.1 Hz, 2H), 2.48 (s, 3H);
13C{1H} NMR (150 MHz, CDCl3) δ 163.9, 149.8, 148.4, 141.8, 141.4, 140.7, 137.3, 136.7, 135.2, 133.4, 129.5, 128.3, 128.0,
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127.4, 126.2, 122.4, 37.0, 20.1; FT-IR: = 3061, 2923, 2853, 1674, 1570, 1516, 1463, 1354, 1303, 1243, 1161, 1084 cm-1;
HRMS calculated for [M+H]+ C20H19N2O3S: 367.1111, found 367.1078.
N-(5-Methoxy-2-(phenylsulfonyl)benzyl)picolinamide (3f); amorphous solid, (79%, 30.2 mg); Rf = 0.38 (40% EA/PE); 1H
NMR (600 MHz, CDCl3) δ 8.71 (t, J = 6.8 Hz, 1H), 8.54 (d, J = 4.8 Hz, 1H), 8.14 (d, J = 9.0 Hz, 2H), 7.89 (d, J = 7.3 Hz, 2H),
7.81 (td, J = 7.7, 1.7 Hz, 1H), 7.55 (t, J = 7.4 Hz, 1H), 7.48 (t, J = 7.4 Hz, 2H), 7.40 (m, 1H), 7.13 (d, J = 2.5 Hz, 1H), 6.93 (dd,
J = 8.9, 2.5 Hz, 1H), 4.76 (d, J = 6.6 Hz, 2H), 3.82 (s, 3H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.5, 164.1, 149.8, 148.4,
~
142.4, 140.2, 137.3, 133.1, 132.6, 130.3, 129.4, 127.2, 126.3, 122.4, 117.5, 113.2, 55.8, 40.8; FT-IR: = 3061, 2924, 2854,
1674, 1570, 1516, 1463, 1435, 1353, 1303, 1243, 1161, 1084 cm-1; HRMS: calculated for [M+H]+ C20H19N2O4S: 383.1060,
found 383.1068.
N-(4-Fluoro-2-(phenylsulfonyl)benzyl)picolinamide (3g); gummy liquid, (51%, 18.9 mg); Rf = 0.28 (40% EA/PE);
1H
NMR (600 MHz, CDCl3) δ 8.70 (t, J = 5.8 Hz, 1H), 8.56 (dt, J = 4.8, 1.3 Hz, 1H), 8.14 (d, J = 7.8 Hz, 1H), 7.95- 7.93 (m, 2H),
7.90 – 7.79 (m, 2H), 7.67 (dd, J = 8.5, 5.3 Hz, 1H), 7.62 (m, 1H), 7.55 (t, J = 7.8 Hz, 2H), 7.42 (m, 1H), 7.25 (m, 1H), 4.79 (d,
J = 6.6 Hz, 2H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.6, 161.7 (d, J = 252.0 Hz), 149.7, 148.4, 140.92, 140.91 (d, J = 24.0
Hz), 137.4, 134.5 (d, J = 7.4 Hz), 133.88, 133.85 (d, J = 3.5 Hz), 129.7, 127.7, 126.4, 122.4, 121.2 (d, J = 20.8 Hz), 117.2 (d, J =
~
24.8 Hz), 39.9; 19F NMR (376 MHz, CDCl3) δ -111.98; FT-IR: = 3061, 2924, 2858, 1672, 1570, 1516, 1464, 1425, 1389,
1303, 1219, 1154, 1089 cm-1; HRMS: calculated for [M+H]+ C19H16FN2O3S: 371.0860, found 371.0873.
1
N-(4-Chloro-2-(phenylsulfonyl)benzyl)picolinamide (3h); amorphous solid, (58%, 22.4 mg); Rf = 0.36 (40% EA/PE); H
NMR (600 MHz, CDCl3) δ 8.68 (t, J = 6.5 Hz, 1H), 8.56 (d, J = 4.8 Hz, 1H), 8.14 (d, J = 7.8 Hz, 2H), 7.94 (d, J = 7.7 Hz, 2H),
7.83 (t, J = 7.8 Hz, 1H), 7.66 – 7.58 (m, 2H), 7.58 – 7.48 (m, 3H), 7.42 (t, J = 6.2 Hz, 1H), 4.80 (d, J = 6.4 Hz, 2H); 13C{1H}
NMR (125 MHz, CDCl3) δ 164.6, 149.6, 148.4, 141.0, 140.6, 137.4, 136.3, 134.5, 134.2, 133.9, 133.7, 129.8, 129.7, 127.7,
~
126.5, 122.4, 40.0; FT-IR: = 3060, 2924, 2852, 1669, 1570, 1518, 1468, 1435, 1358, 1290, 1245, 1154, 1039 cm-1; HRMS:
calculated for [M+H]+ C19H1635ClN2O3S: 387.0565, found 387.0571.
N-(4-Bromo-2-(phenylsulfonyl)benzyl)picolinamide (3i); amorphous solid (56%, 24.2 mg); Rf = 0.40 (40% EA/PE); 1H
NMR (400 MHz, CDCl3) δ 8.66 (t, J = 6.6 Hz, 1H), 8.55 (d, J = 4.5 Hz, 1H), 8.30 (d, J = 2.2 Hz, 1H), 8.13 (d, J = 7.7 Hz, 1H),
7.94 (d, J = 7.7 Hz, 2H), 7.82 (td, J = 7.7, 1.8 Hz, 1H), 7.67 (dd, J = 8.2, 2.2 Hz, 1H), 7.63 (m, 1H), 7.55 (dd, J = 8.1, 6.5 Hz,
3H), 7.41 (m, 1H), 4.78 (d, J = 6.6 Hz, 2H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.6, 149.6, 148.4, 140.9, 140.6, 137.4,
~
137.3, 136.8, 133.9, 132.6, 129.7, 127.7, 126.5, 122.4, 122.2, 40.1; FT-IR: = 3063, 2924, 2853, 1671, 1560, 1517, 1469, 1397,
1361, 1306, 1242, 1153, 1048 cm-1; HRMS: calculated for [M+H]+ C19H1681BrN2O3S: 433.0040, found 433.0053.
N-(2-Chloro-6-(phenylsulfonyl)benzyl)picolinamide (3j); gummy liquid, (57%, 22.1 mg); Rf = 0.32 (40% EA/PE); 1H NMR
(400 MHz, CDCl3) δ 8.49 (d, J = 4.6 Hz, 1H), 8.24 (s, 1H), 8.19 (t, J = 8.1 Hz, 2H), 7.90 (d, J = 7.5 Hz, 2H), 7.82 (t, J = 7.8
Hz, 1H), 7.69 (d, J = 8.0 Hz, 1H), 7.53–7.47 (m, 4H), 7.40 (d, J = 6.1 Hz, 1H), 4.98 (d, J = 5.6 Hz, 2H); 13C{1H} NMR (150
MHz, CDCl3) δ 163.8, 149.7, 148.3, 142.6, 141.1, 138.4, 137.4, 135.7, 134.7, 133.8, 129.7, 129.4, 128.7, 127.7, 126.3, 122.5,
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37.7; FT-IR: = 3063, 2923, 2853, 1672, 1574, 1520, 1466, 1446, 1361, 1288, 1246, 1156, 1044 cm-1; HRMS: calculated for
[M+H]+ C19H1635ClN2O3S: 387.0565, found 387.0577.
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N-(5-Chloro-2-(phenylsulfonyl)benzyl)picolinamide (3k); amorphous solid, (61%, 23.6 mg ); Rf = 0.42 (40% EA/PE) 1H
NMR (400 MHz, CDCl3) δ 8.67 (t, J = 6.7 Hz, 1H), 8.56 (d, J = 4.6 Hz, 1H), 8.15 (d, J = 7.9 Hz, 1H), 8.11 (d, J = 8.3 Hz,
1H),7.91 (d, J = 8.3 Hz, 2H), 7.84 (td, J = 7.7, 1.7 Hz, 1H), 7.62 (s, 1H), 7.60 (d, J = 7.1 Hz, 1H), 7.53 (t, J = 7.7 Hz, 2H), 7.46
– 7.41 (m, 2H), 4.81 (d, J = 6.6 Hz, 2H); 13C{1H} NMR (125 MHz, CDCl3) δ 164.6, 149.6, 148.5, 141.3, 137.43, 137.41,
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133.7, 132.0, 131.9, 131.6, 131.5, 129.7, 128.6, 127.5, 126.5, 122.5, 40.3; FT-IR: = 3063, 2923, 2852, 1674, 1588, 1518,
1465, 1435, 1355, 1307, 1246, 1156, 1048 cm-1; HRMS: calculated for [M+H]+ C19H1635ClN2O3S: 387.0565, found 387.0566.
N-(5-Bromo-2-(phenylsulfonyl)benzyl)picolinamide (3l); amorphous solid, (66%, 28.5 mg); Rf = 0.44 (40% EA/PE); 1H
NMR (400 MHz, CDCl3) δ 8.69 (d, J = 6.8 Hz, 1H), 8.57 (d, J = 4.7 Hz, 1H), 8.16 (d, J = 7.6 Hz, 1H), 8.02 (d, J = 8.4 Hz, 1H),
7.91 (d, J = 7.6 Hz, 2H), 7.84 (td, J = 7.7, 1.7 Hz, 1H), 7.79 (s, 1H), 7.68 – 7.56 (m, 2H), 7.53 (t, J = 7.6 Hz, 2H), 7.43 (dd, J =
7.5, 4.8 Hz, 1H), 4.81 (d, J = 6.6 Hz, 2H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.6, 149.6, 148.4, 141.2, 139.8, 138.0, 137.5,
~
134.9, 133.8, 131.6, 131.5, 129.7, 129.5, 127.5, 126.5, 122.5, 40.2; FT-IR: = 3061, 2923, 2853, 1673, 1557, 1516, 1464, 1390,
1355, 1308, 1244, 1155, 1047 cm-1; HRMS: calculated for [M+H]+ C19H1679BrN2O3S: 431.0060, found 431.0060.
N-(2-(Phenylsulfonyl)-4-(trifluoromethyl)benzyl)picolinamide (3m); gummy liquid, (42%, 17.7 mg); Rf = 0.26 (40%
EA/PE); 1H NMR (600 MHz, CDCl3) δ 8.70 (s, 1H), 8.57 (d, J = 4.7 Hz, 1H), 8.44 (s, 1H), 8.14 (d, J = 7.8 Hz, 1H), 7.95 (d, J
= 7.8 Hz, 2H), 7.88 – 7.77 (m, 3H), 7.64 (t, J = 7.5 Hz, 1H), 7.57 (t, J = 7.7 Hz, 2H), 7.44 (t, J = 6.2 Hz, 1H), 4.89 (d, J = 6.6
Hz, 2H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.7, 149.4, 148.5, 141.8, 140.7, 140.1, 137.5, 134.1, 132.7, 131.0 (q, J = 33.5
~
Hz) 130.9 (q, J = 3.4 Hz), 129.8, 127.7, 127.1 (q, J = 3.7 Hz), 126.6, 123.2 (q, J = 273.2 Hz), 122.5, 40.3; FT-IR: = 3065,
2923, 2852, 1677, 1616, 1571, 1519, 1448, 1405, 1327, 1229, 1155, 1084 cm-1; HRMS: calculated for [M+H]+ C20H16F3N2O3S:
421.0828, found 421.0838.
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N-(4-Acetyl-2-(phenylsulfonyl)benzyl)picolinamide (3n); amorphous solid, (52%, 20.5 mg), Rf = 0.24 (40% EA/PE); H
NMR (400 MHz, CDCl3) δ 8.70 (d, J = 1.7 Hz, 2H), 8.56 (d, J = 4.4 Hz, 1H), 8.33 – 7.98 (m, 2H), 7.95 (d, J = 7.7 Hz, 2H),
7.83 (td, J = 7.7, 1.7 Hz, 1H), 7.77 (d, J = 7.9 Hz, 1H), 7.62 (m, 1H), 7.55 (dd, J = 8.4, 6.9 Hz, 2H), 7.42 (m, 1H), 4.90 (d, J =
6.6 Hz, 2H), 2.64 (s, 3H); 13C{1H} NMR (100 MHz, CDCl3) δ 196.1, 164.7, 149.5, 148.5, 142.6, 141.0, 139.7, 137.5, 137.0,
~
133.9, 133.5, 132.5, 129.9, 129.7, 127.7, 126.5, 122.5, 40.5, 26.9; FT-IR:  = 3060, 2925, 2855, 1679, 1600, 1519, 1447, 1393,
1358, 1308, 1255, 1154, 1095 cm-1; HRMS: calculated for [M+H]+ C21H19N2O4S: 395.1060, found 395.1067.
Methyl 4-(phenylsulfonyl)-3-(picolinamidomethyl)benzoate (3o); amorphous solid, (58%, 23.8 mg), Rf = 0.34 (40% EA/PE);
1H NMR (400 MHz, CDCl3) δ 8.72 (s, 1H), 8.56 (d, J = 4.6 Hz, 1H), 8.27 (s, 1H), 8.21 (d, J = 8.2 Hz, 1H), 8.19 – 8.07 (m,
2H), 7.99 – 7.87 (m, 2H), 7.83 (td, J = 7.6, 1.7 Hz, 1H), 7.62 (m, 1H), 7.53 (dd, J = 8.4, 6.8 Hz, 2H), 7.42 (t, J = 6.0 Hz, 1H),
4.89 (d, J = 6.5 Hz, 2H), 3.91 (s, 3H); 13C{1H} NMR (150 MHz, CDCl3) δ 165.5, 164.5, 149.6, 148.4, 142.9, 140.8, 138.3,
~
137.4, 135.3, 133.9, 133.1, 130.2, 129.7, 129.4, 127.7, 126.5, 122.5, 52.9, 40.6; FT-IR:  = 3062, 2924, 2856, 1729, 1676,
1614, 1570, 1521, 1464, 1363, 1256 1197, 1156, 1060 cm-1; HRMS: calculated for [M+H]+ C21H19N2O5S: 411.1009, found
411.1031.
N-(4,5-Dimethoxy-2-(phenylsulfonyl)benzyl)picolinamide (3p); amorphous solid, (89%, 36.8 mg); Rf = 0.34 (60% EA/PE);
1H NMR (600 MHz, CDCl3,) δ 8.67 (t, J = 6.5 Hz, 1H), 8.54 (d, J = 4.3 Hz, 1H), 8.13 (d, J = 7.7 Hz, 1H), 7.89 (dd, J = 8.4, 1.3
Hz, 2H), 7.81 (td, J = 7.7, 1.7 Hz, 1H), 7.68 (s, 1H), 7.55 (m, 1H), 7.50 (dd, J = 8.5, 7.0 Hz, 2H), 7.40 (m, 1H), 7.13 (s, 1H),
4.71 (d, J = 6.6 Hz, 2H), 3.96 (s, 3H), 3.91 (s, 3H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.4, 153.4, 149.9, 148.44, 148.42,
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142.6, 137.3, 133.2, 132.2, 130.2, 129.5, 127.0, 126.3, 122.4, 115.1, 112.6, 56.6, 56.5, 40.5; FT-IR: = 3057, 2926, 2856, 1662,
1578, 1486, 1452, 1368, 1302, 1264, 1152, 1096 cm-1; HRMS: calculated for [M+H]+ C21H21N2O5S: 413.1166, found
413.1181.
N-(2,3-Dimethoxy-6-(phenylsulfonyl)benzyl)picolinamide (3q); amorphous solid, (83%, 34.3 mg); Rf = 0.30 (60% EA/PE);
1H NMR (400 MHz, CDCl3) δ 8.49 (d, J = 4.7 Hz, 1H), 8.47 (s, 1H), 8.15 (d, J = 7.7 Hz, 1H), 8.05 (d, J = 8.9 Hz, 1H), 7.92 –
7.83 (m, 2H), 7.79 (td, J = 7.7, 1.6 Hz, 1H), 7.50 – 7.39 (m, 3H), 7.36 (dd, J = 7.5, 4.8 Hz, 1H), 7.02 (d, J = 8.8 Hz, 1H), 4.83
(d, J = 5.9 Hz, 2H), 3.93 (s, 3H), 3.82 (s, 3H); 13C{1H} NMR (100 MHz, CDCl3) δ 163.6, 157.6, 150.1, 149.2, 148.3, 142.2,
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137.2, 133.1, 131.8, 131.4, 129.3, 127.22, 127.19, 126.1, 122.3, 111.0, 61.5, 56.2, 34.3; FT-IR: = 3061, 2924, 2852, 1676,
1576, 1478, 1447, 1356, 1309, 1244, 1156, 1086 cm-1; HRMS: calculated for [M+H]+ C21H21N2O5S: 413.1166, found
413.1175.
N-((3-(Phenylsulfonyl)naphthalen-2-yl)methyl)picolinamide (3r); amorphous solid, (72%, 28.9 mg); Rf = 0.38 (40%
1
EA/PE); H NMR (400 MHz, CDCl3) δ 8.80 (d, J = 4.8 Hz, 2H), 8.55 (d, J = 4.8 Hz, 1H), 8.15 (d, J = 7.8 Hz, 1H), 8.08 (s,
1H), 8.00 (d, J = 7.8 Hz, 1H), 7.95 (d, J = 7.7 Hz, 2H), 7.90 – 7.74 (m, 2H), 7.67 – 7.55 (m, 3H), 7.51 (t, J = 7.6 Hz, 2H), 7.40
(dd, J = 7.6, 4.9 Hz, 1H), 4.91 (d, J = 6.6 Hz, 2H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.4, 149.9, 148.4, 141.6, 137.4, 136.2,
~
135.7, 133.5, 132.5, 132.3, 131.9, 131.6, 129.7, 129.6, 129.3, 128.0, 127.8, 127.5, 126.3, 122.4, 40.8; FT-IR: = 3059, 2923,
2853, 1673, 1590, 1519, 1473, 1446, 1364, 1306, 1220, 1153, 1087 cm-1; HRMS: calculated for [M+H]+ C23H19N2O3S:
403.1111, found 403.1119.
(R)-N-(1-(2-(Phenylsulfonyl)phenyl)ethyl)picolinamide (3s); amorphous solid, (60%, 21.9 mg); Rf = 0.40 (40% EA/PE); 1H
NMR (400 MHz, CDCl3) δ 8.51 (d, J = 4.9 Hz, 1H), 8.32 (d, J = 6.7 Hz, 1H), 8.16 (d, J = 8.0 Hz, 1H), 8.04 (d, J = 4.4 Hz, 3H),
7.79 (t, J = 7.8 Hz, 1H), 7.62 – 7.55 (m, 2H), 7.52 – 7.36 (m, 5H), 5.98 (m, 1H), 1.58 (d, J = 6.7 Hz, 3H); 13C{1H} NMR (125
MHz, CDCl3) δ 163.3, 149.8, 148.1, 144.7, 142.0, 138.2, 137.4, 134.3, 133.2, 130.4, 129.2, 127.9, 127.7, 127.5, 126.3, 122.3,
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46.3, 23.8; FT-IR: = 3065, 2923, 2853, 1673, 1570, 1510, 1447, 1307, 1299, 1153, 1087 cm-1. HRMS: calculated for [M+H]+
C20H19N2O3S: 367.1111, found 367.1120.
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N-((3-(Phenylsulfonyl)furan-2-yl)methyl)picolinamide (3t); amorphous solid, (79%, 27.1 mg); Rf = 0.38 (40% EA/PE); H
NMR (400 MHz, CDCl3) δ 8.62 (s, 1H), 8.58 (d, J = 4.4 Hz, 1H), 8.19 (d, J = 7.8 Hz, 1H), 8.00 (d, J = 8.0 Hz, 2H), 7.85 (t, J =
7.7 Hz, 1H), 7.56 (t, J = 7.0 Hz, 1H), 7.46 (td, J = 8.3, 7.8, 5.8 Hz, 3H), 7.34 (d, J = 1.9 Hz, 1H), 6.59 (d, J = 1.9 Hz, 1H), 5.00
(d, J = 6.4 Hz, 2H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.5, 155.3, 149.4, 148.3, 142.7, 141.9, 137.5, 133.6, 129.5, 127.3,
~
126.6, 124.6, 122.6, 110.3, 35.1; FT-IR: = 3065, 2923, 2853, 1674, 1571, 1516, 1447, 1308, 1216, 1146, 1074 cm-1; HRMS:
calculated for [M+H]+ C17H15N2O4S: 343.0747, found 343.0754.
N-((3-(Phenylsulfonyl)thiophen-2-yl)methyl)picolinamide (3u); amorphous solid, (86%, 30.8 mg); Rf = 0.32 (40% EA/PE);
1H NMR (400 MHz, CDCl3) δ 8.80 (s, 1H), 8.57 (d, J = 4.7 Hz, 1H), 8.17 (d, J = 7.7 Hz, 1H), 7.98 (d, J = 7.7 Hz, 2H), 7.84 (t,
J = 7.7 Hz, 1H), 7.57 (t, J = 7.4 Hz, 1H), 7.49 (t, J = 7.4 Hz, 2H), 7.43 (dd, J = 7.4, 4.9 Hz, 1H), 7.32 (d, J = 5.5 Hz, 1H), 7.20
(d, J = 5.4 Hz, 1H), 5.07 (d, J = 6.6 Hz, 2H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.5, 149.4, 148.4, 147.5, 142.0, 137.5,
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136.6, 133.5, 129.5, 128.2, 127.2, 126.6, 125.1, 122.5, 36.1; FT-IR: = 3061, 2924, 2854, 1672, 1570, 1516, 1446, 1362, 1307,
1218, 1157, 1081 cm-1; HRMS: calculated for [M+H]+ C17H15N2O3S2: 359.0519, found 359.0520.
N-((1-Methyl-6-(phenylsulfonyl)-1H-indol-5-yl)methyl)picolinamide (3v); brown solid, (78%, 31.6 mg); Rf = 0.36 (40%
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EA/PE); H NMR (400 MHz, CDCl3) δ 8.74 (t, J = 6.4 Hz, 1H), 8.52 (d, J = 4.8 Hz, 1H), 8.34 (s, 1H), 8.14 (d, J = 7.9 Hz,
1H), 7.96 – 7.84 (m, 3H), 7.78 (d, J = 7.7 Hz, 1H), 7.48 (dt, J = 15.6, 7.5 Hz, 3H), 7.35 (m, 1H), 7.27 (s, 1H), 6.51 (d, J = 3.0
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Hz, 1H), 4.81 (d, J = 6.6 Hz, 2H), 3.91 (s, 3H); 13C{1H} NMR (100 MHz, CDCl3) δ 164.2, 150.2, 148.3, 142.8, 137.2, 135.0,
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133.6, 132.9, 132.7, 131.1, 129.3, 127.8, 127.1, 126.1, 125.0, 122.3, 112.9, 102.1, 41.0, 33.5; FT-IR: = 3061, 2923, 2858,
1670, 1570, 1517, 1446, 1389, 1303, 1252, 1150, 1085 cm-1; HRMS: calculated for [M+H]+ C22H19N3O3S: 406.1220, found
406.1230.
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N-(2-Tosylbenzyl)picolinamide (4a); amorphous solid, (62%, 22.7 mg); Rf = 0.34 (40% EA/PE); 1H NMR (400 MHz,
CDCl3) δ 8.71 (t, J = 6.6 Hz, 1H), 8.56 (dt, J = 4.7, 1.2 Hz, 1H), 8.16 – 8.13 (m, 2H), 7.88 – 7.77 (m, 3H), 7.65 (dd, J = 7.7, 1.4
Hz, 1H), 7.55 (td, J = 7.6, 1.5 Hz, 1H), 7.46 (td, J = 7.7, 1.4 Hz, 1H), 7.41 (m, 1H), 7.30 (d, J = 8.1 Hz, 2H), 4.84 (d, J = 6.6 Hz,
2H), 2.40 (s, 3H); 13C{1H} NMR (125 MHz, CDCl3) δ 164.5, 149.9, 148.4, 144.5, 139.4, 138.7, 137.8, 137.3, 134.2, 132.3,
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130.1, 129.9, 128.4, 127.6, 126.3, 122.4, 40.6, 21.7; FT-IR: = 3017, 2923, 2853, 1671, 1592, 1516, 1466, 1435, 1361, 1303,
1245, 1152, 1092 cm-1;HRMS: calculated for [M+H]+ C20H19N2O3S: 367.1111, found 367.1123.
N-(2-(4-Methoxyphenylsulfonyl)benzyl)picolinamide (4b); amorphous solid, (65%, 24.8 mg); Rf = 0.30 (40% EA/PE) 1H
NMR (600 MHz, CDCl3) δ 8.67 (s, 1H), 8.55 (d, J = 5.3 Hz, 1H), 8.15 (d, J = 7.7 Hz, 1H), 8.11 (dd, J = 8.0, 1.3 Hz, 1H), 7.86
(d, J = 8.8 Hz, 2H), 7.82 (t, J = 7.8 Hz, 1H), 7.64 (d, J = 7.6 Hz, 1H), 7.54 (td, J = 7.6, 1.3 Hz, 1H), 7.48 – 7.36 (m, 2H), 6.97
(d, J = 8.8 Hz, 2H), 4.86 (d, J = 6.6 Hz, 2H), 3.84 (s, 3H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.4, 163.6, 149.8, 148.4,
~
139.9, 137.6, 137.5, 134.0, 133.0, 132.3, 129.9, 129.7, 128.4, 126.4, 122.5, 114.8, 55.8, 40.6; FT-IR: = 3062, 2923, 2851,
1671, 1593, 1518, 1484, 1435, 1361, 1297, 1261, 1149, 1093 cm-1; HRMS: calculated for [M+H]+ C20H19N2O4S: 383.1060,
found 383.1068.
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N-(2-(4-tert-Butylphenylsulfonyl)benzyl)picolinamide (4c); amorphous solid, (66%, 26.9 mg); Rf = 0.42 (40% EA/PE); H
NMR (400 MHz, CDCl3) δ 8.79 (t, J = 6.7 Hz, 1H), 8.57 (d, J = 4.9 Hz, 1H), 8.16 (dd, J = 8.0, 3.0 Hz, 2H), 7.94 – 7.78 (m,
3H), 7.65 (d, J = 7.6 Hz, 1H), 7.60 – 7.44 (m, 4H), 7.41 (dd, J = 7.6, 4.9 Hz, 1H), 4.86 (d, J = 6.6 Hz, 2H), 1.31 (s, 9H);
13C{1H} NMR (150 MHz, CDCl3) δ 164.5, 157.5, 149.8, 148.4, 139.4, 138.5, 137.8, 137.4, 134.2, 132.4, 130.0, 128.4, 127.4,
~
126.6, 126.3, 122.5, 40.7, 35.4, 31.2; FT-IR: = 3062, 2961, 2853, 1675, 1593, 1518, 1465, 1399, 1308, 1239, 1198, 1157,
1088 cm-1; HRMS: calculated for [M+H]+ C23H25N2O3S: 409.1580, found 409.1586.
N-(2-(m-Tolylsulfonyl)benzyl)picolinamide (4d); amorphous solid, (60%, 21.9 mg); Rf = 0.34 (40% EA/PE); 1H NMR (400
MHz, CDCl3) δ 8.72 (s, 1H), 8.55 (d, J = 4.8 Hz, 1H), 8.15 (d, J = 7.7 Hz, 2H), 7.82 (t, J = 7.7 Hz, 1H), 7.71 (s, 2H), 7.66 (d, J
= 7.6 Hz, 1H), 7.57 (t, J = 7.5 Hz, 1H), 7.48 (t, J = 7.6 Hz, 1H), 7.44 – 7.35 (m, 3H), 4.84 (d, J = 6.5 Hz, 2H), 2.39 (s, 3H);
13C{1H} NMR (150 MHz, CDCl3) δ 164.4, 149.8, 148.4, 141.5, 139.9, 139.1, 137.9, 137.4, 134.4, 134.3, 132.4, 130.0, 129.4,
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128.4, 127.8, 126.3, 124.7, 122.4, 40.6, 21.5; FT-IR: = 3062, 2925, 2853, 1674, 1570, 1519, 1465, 1435, 1361, 1303, 1220,
1152, 1089 cm-1; HRMS: calculated for [M+H]+ C20H19N2O3S: 367.1111, found 367.1131.
N-(2-(3-Methoxyphenylsulfonyl)benzyl)picolinamide (4e); amorphous solid, (66%, 25.2 mg); Rf = 0.28 (40% EA/PE) 1H
NMR (400 MHz, CDCl3) δ 8.69 (s, 1H), 8.55 (d, J = 4.6 Hz, 1H), 8.15 (d, J = 7.9 Hz, 2H), 7.82 (t, J = 7.7 Hz, 1H), 7.67 (d, J =
7.6 Hz, 1H), 7.58 (t, J = 7.5 Hz, 1H), 7.53 – 7.32 (m, 5H), 7.08 (m, 1H), 4.86 (d, J = 6.5 Hz, 2H), 3.83 (s, 3H); 13C{1H} NMR
(150 MHz, CDCl3) δ 164.4, 160.2, 149.8, 148.4, 142.8, 138.9, 138.0, 137.4, 134.4, 132.4, 130.6, 130.1, 128.4, 126.3, 122.4,
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119.8, 119.7, 112.1, 55.9, 40.6; FT-IR: = 3063, 2924, 2853, 1673, 1593, 1519, 1479, 1435, 1362, 1307, 1249, 1152, 1093 cm-
1; HRMS: calculated for [M+H]+ C20H19N2O4S: 383.1060, found 383.1072.
N-(2-(4-Bromophenylsulfonyl)benzyl)picolinamide (4f); amorphous solid, (55%, 23.9 mg), Rf = 0.38 (40% EA/PE) 1H
NMR (600 MHz, CDCl3) δ 8.63 (t, J = 6.5 Hz, 1H), 8.56 (d, J = 4.7 Hz, 1H), 8.15 (d, J = 7.8 Hz, 2H), 7.83 (td, J = 7.7, 1.7 Hz,
1H), 7.78 (d, J = 8.6 Hz, 2H), 7.67 (d, J = 7.6 Hz, 1H), 7.64 (d, J = 8.5 Hz, 2H), 7.59 (t, J = 7.5 Hz, 1H), 7.49 (t, J = 7.7 Hz,
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1H), 7.42 (dd, J = 7.5, 4.7 Hz, 1H), 4.85 (d, J = 6.5 Hz, 2H); 13C{1H} NMR (150 MHz, CDCl3) δ 164.5, 149.7, 148.5, 140.8,
~
138.5, 138.0, 137.5, 134.6, 132.9, 132.5, 130.2, 129.0, 128.8, 128.6, 126.5, 122.4, 40.7; FT-IR: = 3062, 2924, 2854, 1674,
1570, 1519, 1465, 1386, 1355, 1307, 1156, 1092 cm-1 ; HRMS: calculated for [M+H]+ C19H1681BrN2O3S: 433.0040, found
433.0012.
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N-(2-(4-Fluorophenylsulfonyl)benzyl)picolinamide (4g); gummy liquid, (49%, 18.2 mg); Rf = 0.30 (40% EA/PE); H NMR
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(400 MHz, CDCl3) δ 8.63 (s, 1H), 8.55 (d, J = 3.9 Hz, 1H), 8.21 – 8.06 (m, 2H), 7.95 (dd, J = 8.6, 4.7 Hz, 2H), 7.83 (t, J = 7.6
Hz, 1H), 7.67 (d, J = 7.3 Hz, 1H), 7.59 (t, J = 7.3 Hz, 1H), 7.49 (dd, J = 9.2, 6.1 Hz, 1H), 7.42 (dd, J = 7.6, 4.5 Hz, 1H), 7.19
(dd, J = 10.1, 6.7 Hz, 2H), 4.86 (d, J = 6.2 Hz, 2H); 13C{1H} NMR (150 MHz, CDCl3) δ 165.6 (d, J = 256.4 Hz), 164.5, 149.7,
148.4, 138.8, 137.8, 137.7 (d, J = 3.2 Hz), 137.5, 134.5, 132.4, 130.4 (d, J = 9.6 Hz), 130.0, 128.5, 126.4, 122.4, 116.9 (d, J =
~
22.8 Hz), 42.3; 19F NMR (376 MHz, CDCl3) δ -103.61; FT-IR: = 3065, 2923, 2853, 1674, 1590, 1520, 1465, 1405, 1362,
1292, 1238, 1152, 1063 cm-1; HRMS: calculated for [M+H]+ C19H16FN2O3S: 371.0860, found 371.0870.
N-(2-(Naphthalen-2-ylsulfonyl)benzyl)picolinamide (4h); amorphous solid, (70%, 28.2 mg); Rf = 0.40 (40% EA/PE); 1H
NMR (400 MHz, CDCl3) δ 8.67 (t, J = 6.5 Hz, 1H), 8.59 (s, 1H), 8.43 (d, J = 4.7 Hz, 1H), 8.22 (dd, J = 7.9, 1.4 Hz, 1H), 8.11
(d, J = 7.8 Hz, 1H), 7.97 (d, J = 8.0 Hz, 1H), 7.93 (d, J = 8.7 Hz, 1H), 7.87 (d, J = 8.0 Hz, 1H), 7.80– 7.76 (m, 2H), 7.72 – 7.55
(m, 4H), 7.50 (td, J = 7.7, 1.4 Hz, 1H), 7.36 (dd, J = 7.3, 5.1 Hz, 1H), 4.89 (d, J = 6.6 Hz, 2H); 13C{1H} NMR (100 MHz,
CDCl3) δ 164.4, 149.8, 148.3, 139.1, 138.5, 138.0, 137.3, 135.2, 134.4, 132.6, 132.3, 130.2, 130.0, 129.6, 129.4, 128.9, 128.5,
~
128.1, 127.9, 126.3, 122.5, 122.4, 40.7; FT-IR: = 3059, 2924, 2853, 1672, 1570, 1518, 1462, 1432, 1349, 1307, 1222, 1154,
1077 cm-1; HRMS: calculated for [M+H]+ C23H19N2O3S: 403.1111, 403.1105.
N-((3-(Phenylsulfonyl)biphenyl-2-yl)methyl)picolinamide (5); amorphous solid, (63%, 26.9 mg); Rf = 0.42 (60% EA/PE);
1H NMR (400 MHz, CDCl3) δ 8.49 (d, J = 4.7 Hz, 1H), 8.34 (m, 1H), 8.25 (s, 1H), 8.04 (d, J = 7.9 Hz, 1H), 7.91 (d, J = 7.1
Hz, 2H), 7.78 (t, J = 7.7 Hz, 1H), 7.65 – 7.50 (m, 2H), 7.44 (d, J = 6.3 Hz, 3H), 7.40 – 7.30 (m, 4H), 7.21 (d, J = 6.5 Hz, 2H),
4.65 (d, J = 5.1 Hz, 2H); 13C{1H} NMR (100 MHz, CDCl3) δ 163.1, 149.9, 148.2, 146.9, 141.6, 141.1, 139.2, 137.2, 136.4,
~
134.5, 133.3, 129.7, 129.4, 129.1, 128.4, 128.2, 128.1, 127.6, 126.1, 122.3, 38.1; FT-IR: = 3065, 2922, 2852, 1716, 1652,
1588, 1447, 1368, 1308, 1252, 1209, 1155, 1092 cm-1; HRMS: calculated for [M+H]+ C25H21N2O3S: 429.1267, found
429.1273.
3-(Phenylsulfonyl)-2-((pyridin-2-ylmethylamino)methyl)phenyl acetate (6); colorless oil, (66%, 26.2 mg); Rf = 0.36 (60%
EA/PE); 1H NMR (400 MHz, CDCl3) δ 8.53 (d, J = 5.1 Hz, 2H), 8.21 – 8.03 (m, 2H), 7.93 (d, J = 8.0 Hz, 2H).7.80 (t, J = 7.8
Hz, 1H), 7.68 – 7.46 (m, 4H), 7.37 (d, J = 7.3 Hz, 2H), 4.82 (d, J = 6.1 Hz, 2H), 2.39 (s, 3H); 13C{1H} NMR (125 MHz,
CDCl3) δ 169.5, 163.9, 151.2, 150.2, 148.4, 142.0, 141.6, 137.2, 133.7, 130.2, 129.7, 129.2, 129.1, 127.7, 127.6, 126.1, 122.3,
~
34.0, 21.1; FT-IR: = 3062, 2852, 1771, 1678, 1591, 1519, 1464, 1368, 1188, 1250, 1160, 1085 cm-1; HRMS: calculated for
[M+H]+ C21H19N2O5S: 411.1009, found 411.1011.
(Z)-Ethyl 3-hydroxy-2-(3-(phenylsulfonyl)-2-((pyridin-2-ylmethylamino)methyl)phenyl)but-2-enoate (7); green oil, (68%,
32.6 mg); Rf = 0.26 (60% EA/PE); 1H NMR (400 MHz, CDCl3) δ 12.12 (s, 1H), 8.44 (d, J = 4.6 Hz, 1H), 8.12 (d, J = 8.0 Hz,
1H), 7.89 (d, J = 7.8 Hz, 1H), 7.81 (d, J = 8.1 Hz, 2H), 7.68 (t, J = 7.6 Hz, 1H), 7.59 (dt, J = 9.1, 4.4 Hz, 2H), 7.55 – 7.42 (m,
4H). 7.25 (d, J = 6.9 Hz, 1H), 5.26 (d, J = 15.1 Hz, 1H), 5.10 (d, J = 15.1 Hz, 1H), 4.21– 4.08 (m, 2H), 1.54 (s, 3H), 1.21 (t, J =
7.0 Hz, 3H); 13C{1H} NMR (100 MHz, CDCl3) δ 175.1, 170.8, 170.4, 154.2, 148.5, 141.9, 139.1, 137.3, 136.5, 133.6, 133.4,
~
133.0, 129.5, 129.4, 128.0, 127.2, 124.5, 122.5, 108.7, 61.1, 48.3, 18.4, 14.3; FT-IR: = 3065, 2923, 2852, 1735, 1657, 1561,
1446, 1344, 1308, 1252, 1219, 1156, 1092 cm-1; HRMS: calculated for [M+H]+ C25H25N2O6S: 481.1428; found 481.1408.
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(E)-Methyl 2-(7-oxo-6-(2-(phenylsulfonyl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ylidene)acetate (8); green oil,
1
(75%, 32.6 mg); Rf = 0.30 (60% EA/PE); H NMR (400 MHz, CDCl3) δ 9.35 (d, J = 8.1 Hz, 1H), 8.87 (d, J = 4.6 Hz, 1H),
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8.26 (m, 1H), 7.92 (d, J = 7.8 Hz, 2H), 7.66 (m, 1H), 7.62 – 7.53 (m, 3H), 7.53 – 7.47 (m, 2H), 7.03 (d, J = 3.3 Hz, 1H), 5.66
(s, 1H), 5.34 (s, 2H), 3.73 (s, 3H); 13C{1H} NMR (100 MHz, CDCl3) δ 166.1, 165.4, 153.2, 148.3, 144.6, 140.9, 138.2, 136.4,
~
134.7, 134.5, 133.9, 130.1, 129.8, 128.5, 127.7, 127.6, 127.1, 102.4, 52.0, 40.2; FT-IR: = 3067, 2924, 2853, 1738, 1716, 1634,
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1592, 1479, 1446, 1403, 1320, 1197, 1158, 1090 cm-1; HRMS: calculated for [M+H]+ C23H19N2O5S: 435.1009, found
435.1012.
(2-(Phenylsulfonyl)phenyl)methanamine(9); yellow oil, (80%, 19.8 mg); Rf = 0.30 (5% MeOH/DCM); 1H NMR (600 MHz,
DMSO-d6) δ 8.10 (d, J = 7.9 Hz, 1H), 7.87 (d, J = 7.6 Hz, 2H), 7.73 (m, 3H), 7.64 (t, J = 7.7 Hz, 2H), 7.59 (t, J = 7.7 Hz, 1H),
3.99 (s, 2H), 1.90 (s, 2H); 13C{1H} NMR (150 MHz, DMSO-d6) δ 140.9, 137.7, 134.3, 133.8, 130.3, 129.8, 129.2, 128.1,
~
127.1, 41.2; FT-IR: = 3414, 1652, 1022, 995, 824, 761 cm-1; HRMS: calculated for [M+H]+ C13H14NO2S: 248.0740, found
248.0733.
1
2,6-di-tert-Butyl-4-(phenylsulfonylmethyl)phenol (11); red solid, (80%, 28.9 mg); Rf = 0.32 (50% EA/PE); H NMR (400
MHz, CDCl3) δ 7.57 (d, J = 7.9 Hz, 3H), 7.42 (td, J = 7.8, 1.6 Hz, 2H), 6.75 (s, 2H), 5.26 (s, 1H), 4.22 (s, 2H), 1.31 (s, 18H);
~
13C{1H} NMR (100 MHz, CDCl3) δ 154.4, 138.0, 136.2, 133.5, 129.0, 128.8, 127.8, 118.9, 63.3, 34.3, 30.2.; FT-IR: = 3662,
2956, 2871, 1718, 1585, 1433, 1360, 1315, 1225, 1085 cm-1; HRMS: calculated for [M+Na]+ C21H28NaO3S: 383.1651, found
383.1666.
ASSOCIATED CONTENT
Supporting information:
Procedures along with results from optimization, control, and deuteration experiments. Crystallographic data and NMR
spectra. This material is available free of charge via the Internet at http://pubs.acs.org.
AUTHER INFORMATION
*E-mail: rsamanta@chem.iitkgp.ac.in
Notes:
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
Financial support by the CSIR, India [02(0323)/17/EMR-II] is gratefully acknowledged. Authors thank DST, India
(SR/FST/CSII-026/2013) for 500 MHz NMR facility, CRF(IIT Kharagpur) for the analytical facility and IIT Kharagpur for
fellowship (UK). We sincerely thank Prof. S. Nanda, IIT Kharagpur for HPLC data.
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