Remarkable salt effect on in-mediated allylation of N-tert-butanesulfinyl imines in aqueous media: Highly practical asymmetric synthesis of chiral homoallylic amines and isoindolinones

Article abstract of DOI:10.1021/ol8001514

A highly practical and efficient asymmetric synthesis of chiral homoallylic amines by In-mediated allylation of chiral N-tert-butanesulfinyl imines in aqueous media at room temperature was developed. With 2-formylbenzoate imine substrates, the method allows the highly enantioselective achievement of a variety of pharmacologically important 3-allyl isoindolinone compounds.