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Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists

DOI: 10.1016/j.bmc.2007.10.007

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Bioorganic and Medicinal Chemistry p. 981 - 994 (2008)

Update date:2022-08-04

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Authors:

Asaki, TetsuoAsaki, Tetsuo

Aoki, TomiyoshiAoki, Tomiyoshi

Hamamoto, TaisukeHamamoto, Taisuke

Sugiyama, YukiteruSugiyama, Yukiteru

Ohmachi, ShinjiOhmachi, Shinji

Kuwabara, KenjiKuwabara, Kenji

Murakami, KohjiMurakami, Kohji

Todo, MakotoTodo, Makoto

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Article abstract of DOI:10.1016/j.bmc.2007.10.007

A series of 1,3-dioxane carboxylic acid derivatives was synthesized and evaluated for human PPAR transactivation activity. Structure-activity relationships on the phenyloxazole moiety of the lead compound 3 revealed that the introduction of small hydropho

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Full text of DOI:10.1016/j.bmc.2007.10.007

Products guided by the article

Product name:methyl 2-methyl-c-5-{4-[2-(4-methylphenyl)-5-(trifluoromethyl)-1,3-oxazol-4-yl]butyl}-1,3-dioxane-r-2-carboxylate

Cas No:1016571-96-2

1016571-96-2

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