
Tetrahedron Letters p. 1439 - 1442 (1997)
Update date:2022-08-04
Topics:
Tatsuta, Kuniaki
Yasuda, Shohei
Kurihara, Ken-Ichi
Tanabe, Kiyoshi
Shinei, Rie
Okonogi, Tsuneo
Microbial metabolites (-)-PF1092A, B and C belonging to an eremophilane sesquiterpene group are synthesized from (R)-5-hydroxymethyl-2(5H)-furanone through the SnCl4 promoted cyclization of an α-keto methyl sulfone and dimethyl acetal followed by a Stork annulation which gives the octalone core.
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