Synthesis and antimalarial activity of new analogues of amodiaquine

DOI: 10.1016/j.ejmech.2007.03.008

Source and publish data:

European Journal of Medicinal Chemistry p. 252 - 260 (2008)

Update date:2022-07-29

Topics: Synthesis Chemical reactions Analogues Antimalarial activity Experimental Design

Authors:

Delarue-Cochin, Sandrine

Paunescu, Emilia

Maes, Louis

Mouray, Elisabeth

Sergheraert, Christian

Grellier, Philippe

Melnyk, Patricia

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Article abstract of DOI:10.1016/j.ejmech.2007.03.008

In order to determine the real significance of the 4′-phenolic group in the antimalarial activity and/or cytotoxicity of amodiaquine (AQ), analogues for which this functionality was shifted or modified were synthesized. Good in vitro antimalarial activity

Full text of DOI:10.1016/j.ejmech.2007.03.008

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