Reaction of rosmarinic acid with nitrite ions in acidic conditions: Discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents

Article abstract of DOI:10.1021/jm7011134

Rosmarinic acid was reacted with nitrite ions under acidic conditions to give 6′-nitro- and 6′,6″-dinitrorosmarinic acids according to the reaction time. Both compounds were active as HIV-1 integrase inhibitors at the submicromolar level. They also inhibi