Peptidyl Carbamates Incorporating Amino Acid Isosteres as Novel Elastase Inhibitors

DOI: 10.1021/jm00158a025

Source and publish data:

Journal of Medicinal Chemistry p. 1468 - 1476 (1986)

Update date:2022-08-04

Topics:

Authors:

Digenis, George A.

Agha, Bushra J.

Tsuji, Kiyoshi

Kato, Masayuki

Shinogi, Masaki

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Article abstract of DOI:10.1021/jm00158a025

The design and synthesis of 13 novel peptidyl carbamates are described.When tested for inhibitory activity toward porcine pancreatic elastase, trypsin, and chymotrypsin, six compounds were found to specifically inhibit lastase without affecting the other

Full text of DOI:10.1021/jm00158a025

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