Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase

DOI: 10.1021/jm201550q

Source and publish data:

Journal of Medicinal Chemistry p. 4580 - 4593 (2012)

Update date:2022-08-02

Topics:

Authors:

Gingrich, Diane E.

Lisko, Joseph G.

Curry, Matthew A.

Cheng, Mangeng

Quail, Matthew

Lu, Lihui

Wan, Weihua

Albom, Mark S.

Angeles, Thelma S.

Aimone, Lisa D.

Haltiwanger, R. Curtis

Wells-Knecht, Kevin

Ott, Gregory R.

Ghose, Arup K.

Ator, Mark A.

Ruggeri, Bruce

Dorsey, Bruce D.

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Article abstract of DOI:10.1021/jm201550q

Anaplastic lymphoma kinase (ALK) is a promising therapeutic target for the treatment of cancer, supported by considerable favorable preclinical and clinical activities over the past several years and culminating in the recent FDA approval of the ALK inhib

Full text of DOI:10.1021/jm201550q

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