Synthesis of isotopically-labelled nitroxyl radicals for use as spin probes

Article abstract of DOI:10.1002/jlcr.2580340711

The synthesis of [15N]-1,1,3,3-tetrakis(trideuteriomethyl)isoindolin-2-yloxyl and of some 5-alkyl derivatives have been achieved by standard synthetic routes. The presence of deuterium improves the sharpness of the signals, and this, together with the incorporation of nitrogen-15, enhances the application of such compounds as spin probes; allyl substituents at C-5 improve the lipophilicity.