A diastereo- and enantioselective synthesis of α-substituted syn-α,β-diamino acids

Article abstract of DOI:10.1021/ja8011808

Highly diastereo- and enantioselective additions of substituted α-nitroesters to imines have been developed. High diastereoselection relies on the finding that the combination of chiral proton catalyst 2b and α-nitro aryl esters bearing 2,6-disubstitution