Synthesis and Structure-Activity Relationships of a Novel Class of 5-Lipoxygenase Inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: The Development of L-656,224

DOI: 10.1021/jm00126a008

Source and publish data:

Journal of Medicinal Chemistry p. 1190 - 1197 (1989)

Update date:2022-07-31

Topics:

Authors:

Lau, Cheuk K.

Belanger, Patrice C.

Scheigetz, John

Dufresne, Claude

Williams, Haydn W. R.

et al. et al.

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Article abstract of DOI:10.1021/jm00126a008

The synthesis of a series of 2-(phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans and their inhibitory effects against leukotriene biosynthesis and 5-lipoxygenase activity in vitro are described.Many compounds of this series were found to be potent inhibitor

Full text of DOI:10.1021/jm00126a008

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