An improved synthesis of cyclic hydroxamic acids from Gramineae

Article abstract of DOI:10.1080/00032719808006490

The boron trichloride sensitive methoxymethyl (MOM) protecting group has been used to efficiently synthesize polymethoxylated derivatives of the benzoxazinone family of cyclic hydroxamic acids. The MOM group allows the unveiling of the hemiacetal at C-2 of these compounds without demethylating ring methoxy substituents, resulting in greatly increased yields.

Full text of DOI:10.1080/00032719808006490

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An Improved Synthesis of
Cyclic Hydroxamic Acids
from Gramineae
Kevin Tays a & Jeffrey Atkinson b
a Guilford Pharmaceuticals Inc., 6611, Tributary
St., Baltimore, MD, 21224, USA
b Brock University, Department of Chemistry, St.
Catharines, Ontario, Canada, L2S 3A1 E-mail:
Version of record first published: 20 Aug 2006
To cite this article: Kevin Tays & Jeffrey Atkinson (1998): An Improved Synthesis
of Cyclic Hydroxamic Acids from Gramineae , Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry,
28:5, 903-912
To link to this article: http://dx.doi.org/10.1080/00032719808006490
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