A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase

DOI: 10.1039/b209613g

Source and publish data:

Organic and Biomolecular Chemistry p. 21 - 23 (2003)

Update date:2022-08-05

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Authors:

Ahmed, Raef

Leeper, Finian J.

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Article abstract of DOI:10.1039/b209613g

Two analogues of porphobilinogen, the 6-methyl and 6,11-ethano derivatives, have been made by a new synthetic route and the 6-methyl analogue has proved to be the most potent inhibitor of hydroxymethylbilane synthase yet reported (K_i = 3 μM).

Full text of DOI:10.1039/b209613g

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