Synthesis of 2-fluoro- acids, esters, and amides from α-dicyanoepoxides

Article abstract of DOI:10.1080/00397919608003723

The opening of α-dicyanoepoxides by pyridine polyhydrofluoride yields polymerisable 2-fluorocyanoformyls which may be kept intact when diluated in dichloromethane or ether. These intermediates react with nucleophiles such as water, methanol or amines to give respectively 2-fluoroacids, esters or amides.