
Chemical and Pharmaceutical Bulletin p. 950 - 955 (1999)
Update date:2022-08-02
Topics:
Pellegrini, Nadia
Refouvelet, Bernard
Crini, Gregorio
Blacque, Olivier
Kubicki, Marek M.
Robert, Jean-Francois
New dipeptides, structural analogues of known immunomodulating agents, were prepared by stereospecific condensation between 2-substituted thiazolidine-4-carboxylate esters with N-substituted L-proline or L- thiaproline. The structure of these compounds has been elucidated by combination of NMR methods and X-ray analysis. In addition, NMR measurements on dipeptides indicated the presence of S-cis and S-trans conformers around the amide bonds.
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