European Journal of Organic Chemistry p. 669 - 674 (2002)
Update date:2022-07-31
Topics:
Schmidt, Matthias
Dobner, Bodo
Nuhn, Peter
We describe the synthesis of polyantennary glycolipid clusters with pentaerythritol cores. A known protecting group strategy permits the introduction of different hydrophobic moieties and the selective coupling with ethyleneoxy spacers of different lengths. After glycosidation, substances with one, two or three mannose residues as terminal carbohydrate headgroups were isolated. These polyantennary mannosides can be used as attractive tools for targeting of liposomes towards the macrophage mannose receptor.
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