The preparation of substituted 1(2H)-isoquinolinones from polylithiated 2-(2-methylphenyl)hydrazinecarboxylic acid esters

Article abstract of DOI:10.1080/00397919608002616

2-(2-methylphenyl)hydrazinecarboxylic acid esters were metalated with excess lithium diisopropylamide, and the resulting polyanion-type intermediates were condensed with aromatic esters followed by acid cyclization to the 3-substituted-1(2H)-isoquinolinon

Full text of DOI:10.1080/00397919608002616

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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The Preparation of Substituted
1(2H)-Isoquinolinones
from Polylithiated 2-(2-
Methylphenyl)Hydrazinecarboxylic
Acid Esters
Madlene U. Koller a , Cameron A. Church a ,
Cynthia L. Griffith a , Margaret A. Hines a , Rene J.
Lachiocotte a , Richard A. Taylor a & Charles F. Beam
a
a Department of Chemistry and Biochemistry ,
College of Charleston , Charleston, South Carolina,
29424
Published online: 21 Aug 2006.
To cite this article: Madlene U. Koller , Cameron A. Church , Cynthia L. Griffith ,
Margaret A. Hines , Rene J. Lachiocotte , Richard A. Taylor & Charles F. Beam
(1996) The Preparation of Substituted 1(2H)-Isoquinolinones from Polylithiated 2-
(2-Methylphenyl)Hydrazinecarboxylic Acid Esters, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 26:9,
1763-1774, DOI: 10.1080/00397919608002616
To link to this article: http://dx.doi.org/10.1080/00397919608002616
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