Tetrahedron Letters p. 4747 - 4750 (1993)
Update date:2022-07-30
Topics:
Feigelson, Gregg B.
A new approach to formation of the carbapenem ring system is presented. The key step involves the Lewis acid mediated cyclocondensation of a β-lactam nitrogen and the α-keto ester of a suitably disposed side-chain. The preparation of a known and pivotal intermediadate in the synthesis of thienamycin serves to demonstrate this strategy.
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Doi:10.1021/acs.jmedchem.8b00673
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(2017)Doi:10.1016/j.tet.2014.06.051
(2014)Doi:10.1016/0008-6215(87)80212-4
(1987)Doi:10.1055/s-2008-1032080
(2008)Doi:10.1016/j.tetlet.2008.02.145
(2008)
