Thiol Addition to Quinones: Model Reactions for the Inactivation of Thymidylate Synthase by 5-p-Benzoquinonyl-2'-deoxyuridine 5'-Phosphate

Article abstract of DOI:10.1021/jm00159a025

The reaction of methyl mercaptoacetate (5) with phenyl-p-benzoquinone (6) or 5-p-benzoquinonyl-3',5'-di-O-acetyl-2'-deoxyuridine (10) resulted in the formation of the three possible adducts to the quinone rings of 6 and 10; an additional product in the re