Potential Antitumor Agents. 47. 3'-Methylamino Analogues of Amsacrine with in Vivo Solid Tumor Activity

DOI: 10.1021/jm00159a035

Source and publish data:

Journal of Medicinal Chemistry p. 1769 - 1776 (1986)

Update date:2022-07-30

Topics:

Authors:

Atwell, Graham, J.

Baguley, Bruce C.

Finlay, Graeme J.

Rewcastle, Gordon W.

Denny, William A.

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Article abstract of DOI:10.1021/jm00159a035

Replacement of the 3'-methoxy group of the clinical antileukemic agent amsacrine (1) with a 3'-methylamino group provides a compound (3) with a broader spectrum of action, including in vivo activity against experimental solid tumors.The synthesis, physico

Full text of DOI:10.1021/jm00159a035

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