Potential Antitumor Agents. 47. 3'-Methylamino Analogues of Amsacrine with in Vivo Solid Tumor Activity

Article abstract of DOI:10.1021/jm00159a035

Replacement of the 3'-methoxy group of the clinical antileukemic agent amsacrine (1) with a 3'-methylamino group provides a compound (3) with a broader spectrum of action, including in vivo activity against experimental solid tumors.The synthesis, physico