Tetrahedron p. 5089 - 5106 (1985)
Update date:2022-07-30
Topics: Aldol Reactions Enolates Diastereofacial Selectivity
Meyers, A. I.
Walkup, Robert D.
The lithium enolate of ethyl dithioacetate reacts with α-methyl aldehydes to yield the aldol products in which the syn configuration in the positions β and γ to the thiocarbonyl of the product is favored over the anti configuration.This selectivity is solvent-dependent, and is enhanced at lower temperatures.In most cases, syn:anti product ratios obtained under these conditions varied from 57:43 to >99:1, depending upon the structure of the α-methyl aldehyde.When the lithium enolate of ethyl dithiopropionate was allowed to react with α-methyl aldehydes, only two out of the four possible diastereomers were detected in the product mixtures.
View MoreChengdu Baishixing Science and Technology Industry Co., Ltd.
website:http://www.cd-bsx.com
Contact:+86-28-88531548
Address:#217,North of Industry Road,Heshan Town,Pujiang County,Chengdu,Sichuan,China.
Contact:+44 7958 511245
Address:PO Box 469, Manchester, UK
Shenyang Xinyihan Chemical Technology Co., Ltd.
Contact:+86-18525026267
Address:362, aigongbeijei street 23 , tiexi district,Shenyang, Liaoning, China
Shandong Loyal Chemical industrial Co.,Ltd
Contact:0533-7451788
Address:Linzi Chemical Industrial Park, Zibo, Shandong Province
website:http://www.chemdow.com
Contact:0086-10-82435335
Address:Room 401,Unit 3,4th Floor,Shangdijiayuan,Shangdi East Road, Haidian District,Beijing
Doi:10.1016/j.phytochem.2010.01.016
(2010)Doi:10.1080/00397910801914160
(2008)Doi:10.1016/S0040-4039(01)01872-X
(2001)Doi:10.1021/ja710822g
(2008)Doi:10.1021/ja8012962
(2008)Doi:10.1039/b306117e
(2003)
