Synthesis and estrogen receptor binding of 6,7-dihydro-8-phenyl-9-[4-[2-(dimethylamino)ethoxy]phenyl]-5 H-benzocycloheptene, a nonisomerizable analogue of tamoxifen. X-ray crystallographic studies

Article abstract of DOI:10.1021/jm00160a044

Syntheses of the title compound, a novel nonisomerizable antiestrogen containing a seven-membered ring, are described. In one method, 6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene was brominated at the 8-position and the bromine displaced by phenyl